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MetabolomicsRat serum transcriptomic data

study investigated the anti-fatigue effect of the Panax ginseng–Astragali Radix (GGJ) herb pair, the core functional unit of Baoyuan Decoction, using a rat fatigue model induced by forced swimming. Serum samples were collected for untargeted metabolomics analysis by LC-MS/MS to profile differenti...

2026-06-30 | MTBLS14902 | MetaboLights
MetabolomicsSerum protein N-glycosylation changes in multiple myeloma

BACKGROUND: Multiple myeloma is characterized by clonal proliferation of malignant plasma cells in the bone marrow that produce monoclonal immunoglobulins. N-glycosylation changes of these monoclonal immunoglobulins have been reported in multiple myeloma, but previous studies on...

2022-04-27 | MTBLS676 | MetaboLights
MetabolomicsTemporal characterization of serum metabolite signatures in lung cancer patients undergoing treatment
Lung cancer causes more deaths in men and women than any other cancer related disease. Currently, few effective strategies exist to predict how patients will respond to treatment. We evaluated the serum metabolomic profiles of 25 lung cancer patients undergoing chemotherapy ± radiation to evaluate t...
2017-01-19 | MTBLS200 | MetaboLights
Metabolomicstargeted metabolomics of rat's serum
Podophyllotoxin (PPT) exhibits limited clinical utility due to its nephrotoxicity, and its underlying mechanisms remain poorly understood. This study employs the toxicological evidence chain (TEC) framework and integrated multi-omics analyses to investigate the potential involvement of the microbiot...
2026-06-27 | MTBLS14868 | MetaboLights
MetabolomicsA serum nuclear magnetic resonance-based metabolomic signature of antiphospholipid syndrome
Antiphospholipid syndrome (APS) is a rheumatic inflammatory chronic autoimmune disease inducing hypercoagulable state associated with vascular thrombosis and pregnancy loss in women. Cardiac, cerebral and vascular strokes in these patients are responsible for reduction in life expectancy. Timely dia...
2017-09-06 | MTBLS356 | MetaboLights
MetabolomicsHigh-confidence untargeted lipidomics of mammalian serum using LC-TIMS-PASEF

This study aimed to establish and validate a robust untargeted lipidomics workflow for the analysis of human serum using reversed-phase liquid chromatography coupled to trapped ion mobility spectrometry time-of-flight mass spectrometry (RP-LC-TIMS-TOF MS). Commercial pooled human serum was used a...

2026-05-26 | MTBLS14002 | MetaboLights
MetabolomicsSerum Metabolomic Profiling Reveals Load-Specific Adaptations to Resistance Training
This study deposits the untargeted ¹H-NMR serum metabolomics dataset of a parallel-group, longitudinal resistance training intervention designed to identify load-specific and training-status-specific metabolomic signatures in healthy young men. Seventeen healthy young men (age 24 ± 3 yr; height 173 ...
2026-07-20 | MTBLS15091 | MetaboLights
MetabolomicsSerum metabolomics identifies unique inflammatory signatures to distinguish rheumatoid arthritis responders and non-responders to TNF inhibitor therapy
Rheumatoid arthritis (RA) is an auto-immune disease which causes irreversible damage to tissue and cartilage within synovial joints. Rapid diagnosis and treatment with disease-modifying therapies is essential to reduce inflammation and prevent destruction of the joint. RA is a heterogeneous disease,...
2025-08-14 | MTBLS6213 | MetaboLights
MetabolomicsTissue, urine and serum NMR metabolomics dataset from a 5/6 nephrectomy rat model of chronic kidney disease

Serum, urine and tissue from a rat model of chronic kidney disease (CKD) were analysed using nuclear magnetic resonance (NMR) spectroscopy-based metabolomics methods, and compared with samples from sham operated rats. Both urine and serum were sampled at multiple timepoints, and the results have ...

2020-11-16 | MTBLS2052 | MetaboLights
MetabolomicsNuclear Magnetic Resonance-Based Blood Metabolic Profiles of Rats Exposed to Short-Term Caloric Restriction
Caloric restriction increases life-span of a number of organisms. The relationship between the increase in life-span and the extent of caloric restriction, however, varies among species. The underlying mechanisms are yet unknown, but appear to be related to changes in metabolism. In order to investi...
2014-09-05 | MTBLS114 | MetaboLights
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