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ProteomicsDiscovery and characterization of a new class of O-linking oligosaccharyltransferase from bacteria in the Moraxellaceae family
Bacterial protein glycosylation can be mediated by oligosaccharyltransferases (OTases) that transfer a preassembled lipid-linked oligosaccharide or polysaccharide en bloc to acceptor proteins. O-linking OTases transfer O-antigen or capsular polysaccharides to the side chains of serine or threonine r...
ORGANISM(S): Moraxella osloensis 
2022-10-13 | PXD033468 | Pride
Glycosylation M. osloensis 
GenomicsNovel Foxo1-dependent Transcriptional Programs Control Treg Cell Function [ChIP-Seq]
Regulatory T (Treg) cells characterized by expression of the transcription factor forkhead box P3 (Foxp3) maintain immune homeostasis by suppressing self-destructive immune responses1-4. Foxp3 operates as a late acting differentiation factor controlling Treg cell homeostasis and function5, whereas ...
ORGANISM(S): Mus musculus 
2012-09-07 | E-GEOD-40656 | biostudies-arrayexpress
TranscriptomicsEnvironmental functional genes for soil microbes in South East Queensland, Australia
Custom made functional gene micoarray (E-FGA) consisting of 13,056 mRNA-enriched anonymus microbial clones from dirverse microbial communities to profile microbial gene transcript in agricultural soils with low and high flux of N2O. A total of 96 genes displayed expression that differed significantl...
ORGANISM(S): synthetic construct 
2010-08-05 | E-GEOD-23422 | biostudies-arrayexpress
UnknownCMTM6-Silencing Microbial Immunotherapy Reprograms PDAC Tumors and Restores T-cell Function.
Not available
S-EPMC12873810 | biostudies-literature
MetabolomicsIdentification of Biomarkers using Metabolomics in Porcine Hemorrhagic Shock
Hemorrhagic shock with injury results in alterations of the metabolic state of an organism, which contribute to organ dysfunction and death. Previous investigations have explored the effects of carbohydrate prefeed in murine models but few in clinically relevant large animal models. We performed car...
2015-01-31 | MTBLS123 | MetaboLights
ProteomicsSystemic effects of cystic fibrosis transmembrane conductance regulator (CFTR) modulators on the plasma and serum proteome
Cystic fibrosis (CF), resulting from a dysfunction in the cystic fibrosis transmembrane conductance regulator (CFTR), affects multiple organs through mucus obstruction and differences in secretion. The CFTR modulator drug combination elexacaftor/tezacaftor/ivacaftor (ELX/TEZ/IVA, ETI) has markedly i...
ORGANISM(S): Homo sapiens (Human) 
2026-04-14 | PXD071549 | Pride
Serum Cystic fibrosis Elx/tez/iva Plasma Astral Dda Cftr modulator Dia Hfx Lum/iva Human Sputum Label free 
GenomicsComprehensive mapping of long-range interactions reveals folding principles of the human genome.
We describe Hi-C, a method that probes the three-dimensional architecture of whole genomes by coupling proximity-based ligation with massively parallel sequencing. We constructed spatial proximity maps of the human genome with Hi-C at a resolution of 1Mb. These maps confirm the presence of chromosom...
ORGANISM(S): Homo sapiens 
2009-10-09 | E-GEOD-18199 | biostudies-arrayexpress
TranscriptomicsCorneal Gene Expression Analysis
Transplantation of amniotic membrane-expanded limbal epithelium (AMLE) in place of donor tissue grafts results in significantly improved outcomes for patients suffering from severe limbal stem cell deficiency; however the reasons for such superior results are unclear. The purpose of this study was t...
ORGANISM(S): Homo sapiens 
2014-10-02 | E-GEOD-56421 | biostudies-arrayexpress
GenomicsControl of VEGF-A trancriptional programs by pausing and genomic compartmentalization
Vascular endothelial growth factor A (VEGF-A) is a master regulator of vascular development and function. Consequently, VEGF-A regulated gene expression programs have been under heavy research. In this study we study the transcriptional regulation of VEGF-A-responsive genes in primary aortic endothe...
ORGANISM(S): Homo sapiens 
2014-10-27 | E-GEOD-52642 | biostudies-arrayexpress
GenomicsTime-course HoxB4 ChIP-Seq during HSC development from ES cells
Efficient in vitro generation of hematopoietic stem cells (HSCs) from embryonic stem cells (ESCs) holds great promise for cell-based therapies of hematological diseases. To date, HoxB4 remains to be the most effective transcription factor (TF) whose over-expression in ESCs confers long-term repopula...
ORGANISM(S): Mus musculus 
2012-03-23 | E-GEOD-34013 | biostudies-arrayexpress
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