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TranscriptomicsMechanistic evaluation of the insulin response in H4IIE hepatoma cells: New endpoints for toxicity testing?
Transcriptional profiling of insulin exposed H4IIE cells at different time points (6h-24h) to 100 nM insulin, with untreated solvent control cells (blanks). The central role of hepatic insulin resistance in pandemic metabolic diseases urges investigation of the underlying mechanisms of its developme...
ORGANISM(S): Rattus norvegicus 
2012-06-17 | E-GEOD-35697 | biostudies-arrayexpress
TranscriptomicsMechanistic analysis of the model obesogen Tributyltin in the 3T3-L1 cell line
Obesogenic compounds are chemicals that might have an influence on obesity development through in utero or chronic lifetime exposure. Tributyltin (TBT) is one of the most studied obesogenic compounds, inducing adipogenesis in vitro and increasing body fat after in utero exposure of mice. This study ...
ORGANISM(S): Mus musculus 
2013-02-25 | E-GEOD-41340 | biostudies-arrayexpress
TranscriptomicsTranscriptional profile of the tail of zebrafish deiodinase knockdown
The role of deiodinase-mediated TH effects in early vertebrate development is only partially understood. Therefore, we investigated the role of deiodinases during early development of zebrafish until 96 hours post fertilization at the level of the transcriptome, biochemistry, morphology and physiolo...
ORGANISM(S): Danio rerio 
2015-04-10 | E-GEOD-61624 | biostudies-arrayexpress
TranscriptomicsTranscriptional profile of the abdomen of zebrafish deiodinase knockdown
The role of deiodinase-mediated TH effects in early vertebrate development is only partially understood. Therefore, we investigated the role of deiodinases during early development of zebrafish until 96 hours post fertilization at the level of the transcriptome, biochemistry, morphology and physiolo...
ORGANISM(S): Danio rerio 
2015-04-10 | E-GEOD-61623 | biostudies-arrayexpress
TranscriptomicsDaphnia magna exposed to narcotics and polar narcotics - isopropanol
Structural analogues are assumed to elicit toxicity via similar predominant modes of action (MOAs). Currently, MOA categorization of chemicals in environmental risk assessment is mainly based on the physico-chemical properties of potential toxicants. It is often not known whether such classification...
ORGANISM(S): Daphnia magna 
2012-02-01 | E-GEOD-29864 | biostudies-arrayexpress
TranscriptomicsDaphnia magna exposed to narcotics and polar narcotics - methanol
Structural analogues are assumed to elicit toxicity via similar predominant modes of action (MOAs). Currently, MOA categorization of chemicals in environmental risk assessment is mainly based on the physico-chemical properties of potential toxicants. It is often not known whether such classification...
ORGANISM(S): Daphnia magna 
2012-02-01 | E-GEOD-29867 | biostudies-arrayexpress
TranscriptomicsDaphnia magna exposed to narcotics and polar narcotics - ethanol
Structural analogues are assumed to elicit toxicity via similar predominant modes of action (MOAs). Currently, MOA categorization of chemicals in environmental risk assessment is mainly based on the physico-chemical properties of potential toxicants. It is often not known whether such classification...
ORGANISM(S): Daphnia magna 
2012-02-01 | E-GEOD-29862 | biostudies-arrayexpress
TranscriptomicsDaphnia magna exposed to narcotics and polar narcotics - 4-chloroaniline
Structural analogues are assumed to elicit toxicity via similar predominant modes of action (MOAs). Currently, MOA categorization of chemicals in environmental risk assessment is mainly based on the physico-chemical properties of potential toxicants. It is often not known whether such classification...
ORGANISM(S): Daphnia magna 
2012-02-01 | E-GEOD-29856 | biostudies-arrayexpress
TranscriptomicsDaphnia magna exposed to narcotics and polar narcotics - aniline
Structural analogues are assumed to elicit toxicity via similar predominant modes of action (MOAs). Currently, MOA categorization of chemicals in environmental risk assessment is mainly based on the physico-chemical properties of potential toxicants. It is often not known whether such classification...
ORGANISM(S): Daphnia magna 
2012-02-01 | E-GEOD-29854 | biostudies-arrayexpress
TranscriptomicsDaphnia magna exposed to narcotics and polar narcotics - 3,5-dichloroaniline
Structural analogues are assumed to elicit toxicity via similar predominant modes of action (MOAs). Currently, MOA categorization of chemicals in environmental risk assessment is mainly based on the physico-chemical properties of potential toxicants. It is often not known whether such classification...
ORGANISM(S): Daphnia magna 
2012-02-01 | E-GEOD-29857 | biostudies-arrayexpress
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