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ProteomicsBMP2K is an inhibitor of erythroid differentiation that restricts endocytosis and SEC16A-dependent autophagy
Coordination of membrane-related processes inside the cells is facilitated by proteins regulating multiple vesicular trafficking pathways. Bone morphogenetic protein 2-inducible kinase (BMP2K) is a poorly studied ubiquitous protein with the highest expression in the erythroid lineage. We hypothesize...
ORGANISM(S): Homo sapiens (Human) 
2019-07-31 | PXD013542 | Pride
Hek293 Bioid Lc-ms/ms 
ProteomicsNovel phosphorylation substrates reveal a spatially regulated role for AAK1 in cell migration - LFQ proteome profiling to determine the impact of AAK1/BMP2K perturbation
NAKs (Numb-associated kinases) are a relatively unexplored kinase family that interacts with the endocytic machinery. Among NAK members, AAK1 has been linked to disorders such as neuropathic pain, schizophrenia, and Alzheimer's disease. Our goal is to better understand the cellular pathways regulate...
ORGANISM(S): Homo sapiens (Human) 
2026-03-19 | PXD055831 | Pride
Focal adhesions Lc-ms Dia Aak1 Lfq Migration Bmp2k 
UnknownSplicing variation of BMP2K balances abundance of COPII assemblies and autophagic degradation in erythroid cells.
Not available
S-EPMC7473771 | biostudies-literature
ProteomicsNovel phosphorylation substrates reveal a spatially regulated role for AAK1 in cell migration - SILAC proteome profiling to determine the impact of acute AAK1/BMP2K inhibition
NAKs (Numb-associated kinases) are a relatively unexplored kinase family that interacts with the endocytic machinery. Among NAK members, AAK1 has been linked to disorders such as neuropathic pain, schizophrenia, and Alzheimer's disease. Our goal is to better understand the cellular pathways regulate...
ORGANISM(S): Homo sapiens (Human) 
2026-03-19 | PXD055851 | Pride
Focal adhesions Lc-ms Silac Aak1 Migration Dda Bmp2k 
UnknownVitamin D activation of functionally distinct regulatory miRNAs in primary human osteoblasts.
Not available
S-EPMC3663893 | biostudies-literature
UnknownEffects of ADMA upon gene expression: an insight into the pathophysiological significance of raised plasma ADMA.
Not available
S-EPMC1240048 | biostudies-literature
UnknownACKR3 Proximity Labeling Identifies Novel G protein- and β-arrestin-independent GPCR Interacting Proteins.
Not available
S-EPMC10896341 | biostudies-literature
Unknown7,8-dichloro-1-oxo-β-carbolines as a versatile scaffold for the development of potent and selective kinase inhibitors with unusual binding modes.
Not available
S-EPMC3257585 | biostudies-literature
UnknownIdentifying candidate genes for Type 2 Diabetes Mellitus and obesity through gene expression profiling in multiple tissues or cells.
Not available
S-EPMC3888709 | biostudies-literature
UnknownIdentification of Pyrimidine-Based Lead Compounds for Understudied Kinases Implicated in Driving Neurodegeneration.
Not available
S-EPMC8802302 | biostudies-literature
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