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TranscriptomicsFGF inhibition directs BMP4-mediated differentiation of Human Embryonic Stem Cells to syncytiotrophoblast
Bone morphogenetic protein (BMP) signaling is known to support differentiation of human embryonic stem cells (hESCs) into mesoderm and extraembryonic lineages, whereas other signaling pathways can largely influence this lineage specification. Here, we set out to reinvestigate the influence of ACTIVI...
ORGANISM(S): Homo sapiens 
2012-10-17 | E-GEOD-30125 | biostudies-arrayexpress
ProteomicsCirculating endoglin induces hypertension via the upregulated expression of BMP4
Endoglin is a membrane glycoprotein primarily expressed by the vascular endothelium and involved in cardiovascular diseases. Upon the proteolytic processing of the membrane-bound protein, a circulating form of endoglin (soluble endoglin, sEng) can be released, and high levels of sEng have been obser...
ORGANISM(S): Homo sapiens (Human) 
2020-04-23 | PXD016228 | Pride
Tgf-β Endothelial cells Preeclampsia Hypertension Endoglin Hht Bmp4 
TranscriptomicsTranscription profiling of mouse embryonic stem cells populations generated during differentiation in the presence or absence of BMP4
Transcription profiling of the cell populations generated during differentiation in presence or absence of BMP4
ORGANISM(S): Mus musculus 
2008-10-30 | E-TABM-363 | biostudies-arrayexpress
TranscriptomicsEffect of BMP4 and noggin on gene expression in murine R1 ES cells
To confirm that the SMAD1/5- and SMAD4-associated genes are direct transcriptional regulators in mESCs in response to BMP, we treated undifferentiated R1 ES cells with BMP4 or with the BMP4 antagonist noggin, which can inhibit BMP signaling effectively for 4 h. Undifferentiated R1 ES cells were trea...
ORGANISM(S): Mus musculus 
2010-03-07 | E-GEOD-20527 | biostudies-arrayexpress
TranscriptomicsBMP4 initiates human ES cell differentiation
The excitement and controversy surrounding the potential role of human embryonic stem (ES) cells in transplantation therapy have often overshadowed their potentially more important use as a basic research tool for understanding the development and function of human tissues. Human ES cells can prolif...
ORGANISM(S): Homo sapiens 
2005-11-03 | E-GEOD-3553 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rat neural stem cells isolated from embryonic neocortex exposed to BMP4
Neural stem cells from rat E15.5 cortices exposed to BMP4 for 3hrs compared to neural stem cells from timepoint 0.
ORGANISM(S): Rattus norvegicus 
2009-01-29 | E-MEXP-1999 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling of human embryonic stem cell lines induced with BMP4 or Wnt3a or Wnt3a/BMP4.
MIXL1-GFP reporter lines were differentiated as Spin EBs in APEL medium supplemented with Wnt3a alone, BMP4 alone or Wnt3a/BMP4 in combination. EBs induced in the absence of growth factors were used as control. EBs induced with BMP4 or Wnt3a/BMP4 were FACS sorted based on E-CADHERIN and GFP expressi...
ORGANISM(S): Homo sapiens 
2010-01-06 | E-MEXP-2495 | biostudies-arrayexpress
TranscriptomicsFGF2 sustains NANOG and switches the outcome of BMP4 induced human embryonic stem cell differentiation
NANOG has emerged as a central gatekeeper of pluripotency. Here we show that as human embryonic stem (ES) cells exit the pluripotent state, NANOG can play a key role in determining lineage outcome. It has previously been reported that BMPs can induce differentiation of human ES cells into extraembry...
ORGANISM(S): Homo sapiens 
2011-03-03 | E-GEOD-25973 | biostudies-arrayexpress
TranscriptomicsEffect of enforced BMP4 expression on gene expression profile of 4T1.2 whole primary murine mammary tumours
BMP4 is down-regulated in metastatic human and murine mammary tumours. Here we determined the effect of ectopic mouse Bmp4 re-expression on global gene expression patterns in orthotopic primary mammary tumours in syngeneic Balb/c mice. Breast cancer is a major cause of cancer related death in women,...
ORGANISM(S): Mus musculus 
2014-06-01 | E-GEOD-51632 | biostudies-arrayexpress
TranscriptomicsCells with features of totipotency derived from human ESC and iPSC by transient BMP4 exposure
Human pluripotent stem cells (hPSC) exposed to BMP4 (B) and inhibitors of ACTIVIN signaling (A83-01; A) and FGF2 (PD173074; P) in absence of FGF2 (BAP conditions) differentiate into colonies primarily comprised of trophoblast. In an attempt to isolate trophoblast stem cells, colonies of hESC were ex...
ORGANISM(S): Homo sapiens 
2015-06-11 | E-GEOD-62065 | biostudies-arrayexpress
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