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ProteomicsComparative proteomics of liver and plasma on the CDAA rat NASH model
Nonalcoholic steatohepatitis (NASH) is a major cause of liver fibrosis with increasing prevalence worldwide. Currently there are no approved drugs available. The development of new therapies is difficult as diagnosis and staging requires biopsies. Consequently, predictive plasma biomarkers would be ...
ORGANISM(S): Rattus norvegicus (Rat) 
2020-01-28 | PXD014751 | Pride
Lc-msms Plasma Han wistar rat Liver 
ProteomicsBleomycin model of fibrosis and resolution phase in old and young mice
Bleomycin-induced pulmonary fibrosis in mice mimics major hallmarks of idiopathic pulmonary fibrosis, yet in this model it spontaneously resolves over time. We studied molecular mechanisms of fibrosis resolution and lung repair, focusing on transcriptional and proteomic signatures and the effect of ...
ORGANISM(S): Mus musculus (Mouse) 
2023-08-09 | PXD041050 | Pride
Bleomycin Dia Mouse Lung Fibrosis Age 
ProteomicsProteomic profiling of young and old mice in the bleomycin model
The most preclinical used in vivo model to study lung fibrosis is the bleomycin-induced lung fibrosis model in 2-3-month-old mice. Although this model resembles key aspects of idiopathic pulmonary fibrosis (IPF), there are limitations in its predictability for the human disease. One of the main diff...
ORGANISM(S): Mus musculus (Mouse) 
2024-09-10 | PXD026222 | Pride
Bleomycin Idiopathic pulmonary fibrosis Tmt Fusion lumos Lc-ms Lung Sps ms3 C57bl/6j mouse 
ProteomicsBleomycin model of fibrosis and resolution phase in old and young mice
Bleomycin-induced pulmonary fibrosis in mice mimics major hallmarks of idiopathic pulmonary fibrosis, yet in this model it spontaneously resolves over time. We studied molecular mechanisms of fibrosis resolution and lung repair, focusing on transcriptional and proteomic signatures and the effect of ...
ORGANISM(S): Mus musculus (Mouse) 
2024-09-10 | PXD040530 | Pride
Bleomycin Dia Mouse Lung Fibrosis Age 
TranscriptomicsDigoxin and its derivatives suppress Th17 cell differentiation by antagonizing RORγt activity
CD4+ T helper lymphocytes that express interleukin-17 (Th17 cells) have critical roles in mouse models of autoimmunity, and there is mounting evidence that they also influence inflammatory processes in humans. Genome-wide association studies in humans have linked genes involved in Th17 cell differe...
ORGANISM(S): Mus musculus 
2011-03-28 | E-GEOD-27241 | biostudies-arrayexpress
ProteomicsLung proteome of the AAV-DTR/DT mouse model of acute epithelial lung injury
Injury of the lung epithelium is one of the initial events driving acute lung diseases such as acute lung injury and acute respiratory distress syndrome. Repeated epithelial injury followed by aberrant repair leads to fibroblast activation and extracellular matrix deposition and is therefore conside...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2021-12-04 | MSV000088510 | MassIVE
UnknownComparison of Current Optical Coherence Tomography Angiography Methods in Imaging Retinal Hemangioblastomas.
Not available
S-EPMC7422766 | biostudies-literature
TranscriptomicsDox-regulated Notch4 overexpression in mouse ES cells redirects hemagioblasts to a cardiac fate.
Previous studies have demonstrated that distinct progenitor subpopulations of mesoderm display tissue specific and vascular potential: hemangioblasts, a progenitor population capable of generating cells of the hematopoietic, endothelial and vascular smooth muscle lineages, and a multipotential proge...
ORGANISM(S): Mus musculus 
2010-09-15 | E-GEOD-12425 | biostudies-arrayexpress
TranscriptomicsAnalysis of human enteroids and colonoids (3D organoid models from small intestine and colon) exposed to chemotherapy agent 5-fluorouracil (5FU) in a dose-repeated exposure across three doses (10,100 and 1000uM) and sampled at three points (24, 48 and 72h) since initial exposure. Organoids were obtained from healthy human tissues.
ADRs (adverse drug reactions) are one of the main reasons for treatment discontinuation or alterations in dose regimens in clinical settings. Chemotherapy-induced ADRs are common, especially gastrointestinal-induced ones. Within TransQST (transqst.org), one of the main goal is to improve the in vitr...
ORGANISM(S): Homo sapiens 
2021-09-09 | E-MTAB-9134 | biostudies-arrayexpress
UnknownThree-Year Overall Survival with Durvalumab after Chemoradiotherapy in Stage III NSCLC-Update from PACIFIC.
Not available
S-EPMC7244187 | biostudies-literature
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