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ProteomicsActivation of CD44 / AKT signaling promotes resistance to FGFR1 inhibition in squamous cell lung cancer
Lung cancer is the leading cause of cancer related deaths, worldwide. Fibroblast growth factor receptor 1 (FGFR1) gene amplification is one of the most prominent and potentially targetable genetic alterations in squamous cell lung cancer (SQCLC). Highly selective tyrosine kinase inhibitors have been...
ORGANISM(S): Homo sapiens (Human) 
2022-08-12 | PXD025389 | Pride
Cd44 Akt Mass spectrometry Phosphoproteomics Lung cancer Fgfr1 
ProteomicsIdentification of potential biomarkers in testicular cancer by SILAC and mass spectrometry
This study represents a proteomic resource for testis cancer with quantitative protein expression data for 5236 proteins. By quantitative mass-spectrometry-based proteomics, we compared the two Malignant germ cell tumour cell lines, TCam-2 with seminoma-like characteristics, and NTERA-2, an embryona...
ORGANISM(S): Homo sapiens (Human) 
2019-11-12 | PXD010275 | Pride
Testis cancer Silac Biomarker 
TranscriptomicsToward biomarker-guided radiotherapy: Multi-omics analysis links ATM status to radioresistance in lung adenocarcinoma
Lung adenocarcinoma (LUAD) exhibits wide variability in radiotherapy response, yet no validated biomarkers currently guide radiation stratification. The ataxia-telangiectasia mutated (ATM) kinase plays a central role in DNA damage repair, and its loss has been associated with radiosensitivity. This ...
ORGANISM(S): Homo sapiens 
2026-08-30 | E-MTAB-16218 | biostudies-arrayexpress
TranscriptomicsRNAseq of the small intestine of mice 6 days after they were transplanted with either wildtype allogeneic T cells or glucocorticoid-resistant allogeneic T cells (mouse model of acute graft-versus-host disease
Given that mice transplanted with glucocorticoid-resistant T cells display more severe disease symptoms, the idea was that an RNA-seq comparison between mice transplanted with either wildtype or glucocorticoid-resistant T cells could yield genes involved in disease progression and potential therape...
ORGANISM(S): Mus musculus 
2019-03-12 | E-MTAB-7765 | biostudies-arrayexpress
TranscriptomicsRNA Single Cell Sequencing of Colorectal Liver Metastasis regarding their Histopathological Growth Pattern
Molecular characterization of single cells in Colorectal Cancer Liver Metastases (CRCLM) and corresponding healthy liver tissue focusing on the comparison between the two main histopathological growth patterns (HGPs): desmoplastic HGP (dHGP) and replacement HGP (rHGP) with the intent to identify pos...
ORGANISM(S): Homo sapiens 
2023-01-05 | E-MTAB-12022 | biostudies-arrayexpress
ProteomicsHSP90 promotes Burkitt lymphoma cell survival by maintaining tonic B cell receptor signaling
Burkitt’s lymphoma (BL) is an aggressive B-cell neoplasm that is currently treated by intensive chemotherapy in combination with anti-CD20 antibodies. Because of their toxicity, current treatment regimens are often not suitable for elderly patients or for patients in developing countries where BL is...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080781 | MassIVE
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