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ProteomicsEpigenome-wide impact of MAT2A sustains the androgen-indifferent state and confers synthetic vulnerability in ERG fusion-positive prostate cancer
Castration-resistant prostate cancer (CRPC) is a frequently occurring disease with adverse clinical outcomes and limited therapeutic options. Here, we identify a novel role of methionine adenosyltransferase 2a (MAT2A) as a driver of the androgen-indifferent state in ERG fusion-positive CRPC. We show...
ORGANISM(S): Homo sapiens (Human) 
2024-06-06 | PXD042895 | Pride
Androgen-indifferent state Castration-resistant prostate cancer Mat2a Erg Epigenomics 
ProteomicsTargeting FOXA1 and FOXA2 Disrupts the Lineage-Specific Oncogenic Output in Prostate Cancer
Activation of the androgen receptor (AR) is the key lineage-specific oncogenic pathway and the primary therapeutic target in prostate cancer. While AR signaling is enabled by the pioneer transcription factor FOXA1, its homolog FOXA2 is specifically expressed in advanced lineage plasticity prostate c...
ORGANISM(S): Homo sapiens (Human) 
2026-01-27 | PXD057803 | Pride
Foxa1 Ar negative prostate cancer Foxa2 Targeting transcription factor Chromatin 
UnknownCell-cycle inhibition by Helicobacter pylori L-asparaginase.
Not available
S-EPMC2976697 | biostudies-literature
UnknownP1144: RADIOIMMUNOTHERAPY (RIT) VERSUS AUTOLOGOUS HEMATOPOIETIC STEM-CELL TRANSPLANTATION (ASCT) IN RELAPSED/REFRACTORY (R/R) FOLLICULAR LYMPHOMA: A FONDAZIONE ITALIANA LINFOMI (FIL) PHASE III TRIAL.
Not available
S-EPMC9430496 | biostudies-literature
UnknownPrevalence of Single and Multiple Natural NS3, NS5A and NS5B Resistance-Associated Substitutions in Hepatitis C Virus Genotypes 1-4 in Italy.
Not available
S-EPMC5997636 | biostudies-literature
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