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TranscriptomicsBulk RNAseq of punch biopsies following intradermal injection of gold nanoparticles loaded with diabetes autoantigen, or unijected controls, in humans
the Enhanced Epidermal Antigen Specific Immunotherapy Trial -1 (EEASI) study was a two-centre, open-label, uncontrolled, single-group first-in-human Phase 1A safety study of C19-A3 GNP peptide in individuals with T1D (https://clinicaltrials.gov/ct2/show/NCT02837094). The investigational medicinal pr...
ORGANISM(S): Homo sapiens 
2023-10-06 | E-MTAB-13386 | biostudies-arrayexpress
TranscriptomicsSingle-cell RNAseq identifies clonally expanded antigen-specific T-cells following intradermal injection of gold nanoparticles loaded with diabetes autoantigen in humans
Gold nanoparticles (GNPs) have been used in the development of novel therapies as a way of delivery of both stimulatory and tolerogenic peptide cargoes. Here we report that intradermal injection of GNPs loaded with the proinsulin peptide C19-A3, in patients with type 1 diabetes, results in recruitme...
ORGANISM(S): Homo sapiens 
2023-10-06 | E-MTAB-13388 | biostudies-arrayexpress
ProteomicsGlobal discovery of bacterial RNA-binding proteins by RNase-sensitive gradient profiles reports a new FinO domain protein
RNA-binding proteins (RBPs) play important roles in bacterial gene expression and physiology but their true number and functional scope remain little understood even in model microbes. To advance global RBP discovery in bacteria, we here establish glycerol gradient sedimentation with RNase treatment...
ORGANISM(S): Salmonella enterica subsp. enterica serovar Typhimurium str. SL1344 Bacteria 
2020-07-16 | PXD018422 | Pride
Salmonella Yafb Gradr Hfq Csra Proq Faba Rbp 
UnknownThe REstart or STop Antithrombotics Randomised Trial (RESTART) after stroke due to intracerebral haemorrhage: study protocol for a randomised controlled trial.
Not available
S-EPMC5838871 | biostudies-literature
UnknownEffects of Antiplatelet Therapy After Stroke Caused by Intracerebral Hemorrhage: Extended Follow-up of the RESTART Randomized Clinical Trial.
Not available
S-EPMC8417806 | biostudies-literature
UnknownLong-Term Effects of Empagliflozin in Patients with Chronic Kidney Disease.
Not available
S-EPMC7616743 | biostudies-literature
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