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MetabolomicsMetabolic-engineered probiotic-OMVs as nanovaccine mediating sequential immunomodulation for chronic bone infection immunotherapy

Chronic, drug-resistant bone infection caused by methicillin-resistant Staphylococcus aureus (MRSA) features an immunosuppressive niche enabling persistent infection and impaired bone healing. Specific treatment requires initial antibacterial immune activation against infection, followed by resha...

2026-03-19 | MTBLS14091 | MetaboLights
MetabolomicsHarnessing Exogenous Stimuli and Functionally 3D Aligned Fibrous Scaffolds for Spatiotemporal Modulation of Bone Regeneration

Bone regeneration requires spatiotemporal coordination of immune modulation, stem cell recruitment, angiogenesis, and osteogenesis, yet most scaffolds lack sequential control across healing phases. We develop a near-infrared (NIR)-responsive therapeutic platform that integrates clinically av...

2026-03-04 | MTBLS13974 | MetaboLights
ProteomicsProteomic profiling of scaffold-guided bone healing in type 2 diabetes rat model with critical-sized bone defect
Type 2 diabetes mellitus significantly impairs bone healing, with delayed regeneration observed in over 60% of diabetic patients. This study investigated the molecular mechanisms underlying diabetes-associated compromised regeneration using time-resolved proteome profiling of critical-sized femoral ...
ORGANISM(S): Rattus norvegicus (Rat) 
2026-04-16 | PXD071312 | Pride
Genomicsγδ17T Cells Hinder Mandibular Bone Defect Healing
γδ17T Cells Hinder Mandibular Bone Defect Healing
PRJNA1373175 | ENA
ProteomicsOsteogenic human MSC-derived extracellular vesicles regulate MSC activity and osteogenic differentiation and promote bone regeneration in a rat calvarial defect model
The objective of this study was to explore the characteristics and roles of extracellular vesicles (EVs) obtained from human mesenchymal stem cells (MSCs) under two culture conditions: undifferentiated MSCs (Naïve-EVs) and MSCs undergoing early-stage osteogenesis (Osteo-EVs). Additionally, the study...
ORGANISM(S): Homo sapiens (Human) 
2024-01-10 | PXD043335 | Pride
Mesenchymal stem cells Rat calvarial defects. Extracellular vesicles Bone regeneration Naïve-evs Osteo-evs 
ProteomicsComparative intraindividual proteomic analysis of osteogenic differentiated adipose tissue-derived and bone marrow-derived mesenchymal stem cells reveals integrin expression profile as distinctive feature
The treatment of bone defects caused by infection, trauma or neoplasms remains a clinical challenge. Autologous bone transplantation is limited by availability, donor site morbidity and surgical risk factors. This has given rise to stromal/stem-cell based therapy. Bone marrow derived stromal cells (...
ORGANISM(S): Homo sapiens (Human) 
2021-06-09 | PXD015223 | Pride
Dia-based proteomics Bone defect Osteogenic differentiated human stem cells Integrin 
GenomicsEngineering Fibroblast with Reprogramming and Spheronization for Bone Defect Repair
Engineering Fibroblast with Reprogramming and Spheronization for Bone Defect Repair
PRJNA1168097 | ENA
GenomicsEngineering Fibroblast with Reprogramming and Spheronization for Bone Defect Repair
Engineering Fibroblast with Reprogramming and Spheronization for Bone Defect Repair
PRJNA1166210 | ENA
TranscriptomicsGenome-wide gene expression profiling analysis of bone metastases of human non-small cell lung cancer (NSCLC) in mice
Using a multiorgan metastasis model of human NSCLC cells (ACC-LC319/bone2) in NK cell-depleted SCID mice, we attempted to identify genes involved in the organ-selective nature of lung cancer-metastasis process, especially bone metastasis. Genome-wide gene expression profile of 15 metastatic lesions ...
ORGANISM(S): Homo sapiens 
2012-02-21 | E-GEOD-29391 | biostudies-arrayexpress
TranscriptomicsNovel Regulators of Fgf23 Expression and Mineralization in Hyp Bone
We used gene array analysis of cortical bone to identify Phex-dependent gene transcripts regulating Fgf23 production and mineralization in Hyp mice. We discovered that activation of Fgf receptor- and Wnt-pathways contribute to increased Ffg23 gene transcription in Hyp bone. We found evidence in Hyp ...
ORGANISM(S): Mus musculus 
2009-12-21 | E-GEOD-14242 | biostudies-arrayexpress
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