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MetabolomicsPla2g7 regulates bone homeostasis via Alox12/12-HETE/Gpr31 signaling axis

Bone homeostasis mainly depends on the equilibrium of osteoclasts and osteoblasts, overactivated osteoclasts play a pivotal role in the progression of osteoporosis. Here, we revealed that Pla2g7 (phospholipase A2 group VII) was positively correlated with bone resorption in clinic. By single-cell ...

2025-10-30 | MTBLS13141 | MetaboLights
MetabolomicsUridine Attenuates Osteoclastogenesis and Ovariectomy Induced Bone Loss by Modulating the PI3K/Akt–FoxO ROS Signaling Axis

Osteoporosis is a metabolic bone disorder characterized by aberrant osteoclast activation, leading 

to excessive bone resorption and microarchitectural deterioration. Although the interconnection 

between osteoclast differentiation and cellular energy metabolism has been inc...

2026-04-09 | MTBLS13394 | MetaboLights
TranscriptomicsABCC5 supports osteoclast formation and promotes breast cancer metastasis to bone
Bone is the primary site of breast cancer metastasis and complications associated with bone metastases can lead to a significantly decreased quality of life in these patients. Thus, it is essential to gain a better understanding of the molecular mechanisms that underlie the emergence and growth of b...
ORGANISM(S): Homo sapiens 
2012-11-09 | E-GEOD-39494 | biostudies-arrayexpress
GenomicsAnxA1 inhibits pathological bone resorption
AnxA1 inhibits pathological bone resorption
PRJNA759264 | ENA
TranscriptomicsOsteoclast-secreted Cthrc1 in the coupling of bone resorption to formation
Bone remodeling is characterized by the sequential, local tethering of osteoclasts and osteoblasts, and is key to the maintenance of bone integrity. While bone matrix-mobilized growth factors, such as TGF-β, are proposed to regulate remodeling, no in vivo evidence exists that an osteoclast-produced...
ORGANISM(S): Mus musculus 
2015-04-01 | E-GEOD-45656 | biostudies-arrayexpress
ProteomicsProtein sequencing of human bone tissue at different ages
Bone is a dynamic organ in which bone formation mediated by osteoblasts balances against bone resorption mediated by osteoclasts to maintain bone homeostasis. With age, this balance gradually tilts toward bone resorption, leading to bone loss and osteoporosis. At the present study, the bone specimen...
ORGANISM(S): Homo sapiens (Human) 
2023-02-01 | PXD039538 | Pride
Bone Osteoporosis Human Proteome Aging 
TranscriptomicsTranscriptome of the bone metastasis associated stroma
The reciprocal interaction between cancer cells and the tissue-specific stroma is critical for primary and metastatic tumor growth progression. Prostate cancer cells colonize preferentially bone (osteotropism), where they alter the physiological balance between osteoblast-mediated bone formation and...
ORGANISM(S): Mus musculus 
2014-12-09 | E-GEOD-22813 | biostudies-arrayexpress
GenomicsTissue-specific VEGF-D overexpression induces lymphangiogenesis and heterotopic bone resorption
Tissue-specific VEGF-D overexpression induces lymphangiogenesis and heterotopic bone resorption
PRJNA1040282 | ENA
GenomicsGIP acts on multiple signaling pathways to uncouple bone resorption and formation
GIP acts on multiple signaling pathways to uncouple bone resorption and formation
PRJNA828419 | ENA
GenomicsThe miR4261/PAMM axis in multiple myeloma promotes bone resorption
The miR4261/PAMM axis in multiple myeloma promotes bone resorption
PRJNA1395526 | ENA
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