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ProteomicsProteomics in biomanufacturing control: Protein dynamics of CHO-K1 cells and conditioned media during apoptosis and necrosis
Cell viability has a critical impact on product quantity and quality during the biomanufacturing of therapeutic proteins. An advanced understanding of changes in the cellular and conditioned media proteomes upon cell stress and death is therefore needed for improved bioprocess control. Here, a high ...
ORGANISM(S): Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) 
2018-02-27 | PXD008297 | Pride
Proteomics Cho Keywords: biomanufacturing Necrosis Apoptosis 2d-lc-mse 
ProteomicsProteome Analysis of AAV producing HEK293 cells
Adeno-associated viral (AAV) vectors are widely used for gene therapy, providing treatment for diseases caused by absent or defective genes. Despite the success of gene therapy, AAV-manufacturing is still challenging, with production yields being limited. With increased patient demand, improvements ...
ORGANISM(S): Homo sapiens (Human) 
2021-12-09 | PXD028154 | Pride
Hek293 Proteomics Gene therapy Aav Lc-ms/ms Label free 
ProteomicsAnalysis of IgG1 producing CHO cells
The effects of changes in bioprocessing parameters (temp, pH, DO) on anti-IL8 IgG1 producing Chinese hamster ovary (CHO) cells were studied on the level of host cell proteome expression using TMT-SPS-MS3.
ORGANISM(S): Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) 
2021-04-09 | PXD017779 | Pride
Sps-ms3 Tmt Cho 
TranscriptomicsTranscription profiling of mouse R26Pax3 animals palates
We used microarrays to detail the global programme of gene expression underlying palate development by persistent expression in R26Pax3 mice and identified distinct classes of up-regulated and down-regulated genes during this process. Experiment Overall Design: Palatal shelves were dissected at E14....
ORGANISM(S): Mus musculus 
2008-06-18 | E-GEOD-11400 | biostudies-arrayexpress
MetabolomicsOral dysbiosis initiates periodontal disease in experimental kidney disease

BACKGROUND AND HYPOTHESIS: It is presently unclear why there is a high prevalence of periodontal disease in individuals living with chronic kidney disease. Whilst some have argued that periodontal disease causes chronic kidney disease, we hypothesized that alterations in saliva ...

2025-09-04 | MTBLS1833 | MetaboLights
TranscriptomicsTranscription profiling of mouse autograft and allograft samples from femur
Comparison of autograft and allograft samples from C57Bl/6 femur
ORGANISM(S): Mus musculus 
2008-06-11 | E-GEOD-2249 | biostudies-arrayexpress
TranscriptomicsSkeletal Muscle Contraction Reduces Effects of Unloading on Bone Independently from the Central Nervous System: Studies Using Functional Electrical Stimulation after Spinal Cord Transection
Spinal cord injury (SCI) causes severe bone loss and disrupts connections between higher centers in the central nervous system (CNS) and bone. Muscle contraction elicited by functional electrical stimulation (FES) partially protects against loss of bone but cellular and molecular events by which th...
ORGANISM(S): Rattus norvegicus 
2012-06-27 | E-GEOD-30301 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of Bone-Marrow-Derived-Macrophages (5 days of culture) in a backcross population of LEW and WKY
WKY and LEW strains have been widely studied for their differential susceptibility to experimental glomerulonephritis. In particular these strains show strong variations in the macrophage activation. This dataset measures expression of macrophages in backcross population of WKY DC and LEW rats and ...
ORGANISM(S): Rattus norvegicus 
2014-08-31 | E-MTAB-2719 | biostudies-arrayexpress
TranscriptomicsThe effect of homocysteine on human aortic smooth muscle cells
Vascular calcification is a common manifestation of atherosclerosis and involves cell-mediated processes similar to the formation of bone (osteogenesis). Elevated plasma levels of homocysteine are an independent risk factor for atherosclerotic vascular disease but the underlying mechanisms remain un...
ORGANISM(S): Homo sapiens 
2008-10-21 | E-GEOD-9490 | biostudies-arrayexpress
TranscriptomicsNext-generation sequencing facilitates quantitative analysis of diaphysis and metaphysis from femur of 5-week-old Dlx3Oc-cKO and wild type (WT=Dlx3+/+) mice transcriptomes
Purpose: Next-generation sequencing (NGS) has revolutionized systems-based analysis of cellular pathways. The goals of this study are to compare NGS-derived femoral diaphysis and metaphysis transcriptome profiling (RNA-seq) to determine pathways and networks dependent on Dlx3 during bone development...
ORGANISM(S): Mus musculus 
2014-11-04 | E-GEOD-53105 | biostudies-arrayexpress
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