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MetabolomicsCaridac untargeted lipidomics in Sham or TAC-operated mice pretreated with AAV9-NC or AAV9-cTnT-shSlc9a3

Background: Heart failure with reduced ejection fraction (HFrEF) is characterized by impaired contractility and high mortality. Dysregulation of intracellular ion cycling underlies the decline in cardiac contractility. Modulation of cardiac Na+/H+ and Ca2+ handling is consider...

2026-02-20 | MTBLS13701 | MetaboLights
ProteomicsMagnetic resonance imaging and transcriptome-proteome integration analysis demonstrate improved disease-outcome in the cuprizone mouse model following AAV-mediated delivery of A Proliferation Inducing Ligand
A Proliferation Inducing Ligand (APRIL) is a member of the tumour necrosis factor (TNF) superfamily and has recently been shown to modulate pro-inflammatory astrocyte responses, as well as to ameliorate disease outcome in the experimental autoimmune encephalomyelitis mouse model for multiple scleros...
ORGANISM(S): Mus musculus (Mouse) 
2025-11-10 | PXD056011 | Pride
Cuprizone Adeno-associated virus Neuroprotection Neuroinflammation Magnetic resonance imaging Transcriptomics Proteomics April 
TranscriptomicsGenotoxicity after adeno-associated virus (AAV) gene therapy is dependent upon dose, treatment age and enhancer-promoter selection
AAV gene therapy has recently been approved for clinical use and shown to be efficacious and safe in a growing number of clinical trials. However, the safety of AAV as a gene therapy has been challenged by a few studies that documented hepatocellular carcinoma (HCC) after AAV gene delivery in mice. ...
ORGANISM(S): Mus musculus 
2015-01-01 | E-GEOD-57597 | biostudies-arrayexpress
TranscriptomicsSingle nucleus RNAseq of mouse inguinal white adipose tissue with Rspo2 or GFP AAV injection
We injected AAV to overexpress Rspo2 or GFP in mice, performed single nucleus RNAseq for inguinal white adipose tissue (ingWAT).
ORGANISM(S): Mus musculus 
2021-12-07 | E-MTAB-11104 | biostudies-arrayexpress
ProteomicsFast & High Throughput LC-MS Characterization, and Peptide Mapping of Engineered AAV Capsids Using LC-MS/MS
Adeno-associated virus (AAV) has emerged as a leading platform for gene therapy. With a skyrocketing rate of AAV research and the prevalence of many new engineered capsids being investigated in preclinical and clinical trials, capsid characterization plays an important role in serotype confirmation ...
ORGANISM(S): Adeno-associated virus 9 
2023-03-11 | PXD035837 | Pride
Peptide map. Aav capsids Engineered aav capsids Lcms Msms 
ProteomicsProteome Analysis of AAV producing HEK293 cells
Adeno-associated viral (AAV) vectors are widely used for gene therapy, providing treatment for diseases caused by absent or defective genes. Despite the success of gene therapy, AAV-manufacturing is still challenging, with production yields being limited. With increased patient demand, improvements ...
ORGANISM(S): Homo sapiens (Human) 
2021-12-09 | PXD028154 | Pride
Hek293 Proteomics Gene therapy Aav Lc-ms/ms Label free 
TranscriptomicsA multi-functional AAV-CRISPR-Cas9 and its host response
CRISPR-Cas9 delivery by AAV holds promise for gene therapy but faces critical barriers due to its potential immunogenicity and limited payload capacity. Here, we demonstrate genome engineering in postnatal mice using AAV-split-Cas9, a multi-functional platform customizable for genome-editing, transc...
ORGANISM(S): Mus musculus 
2016-07-29 | E-GEOD-84534 | biostudies-arrayexpress
ProteomicsAnalysis of Protein Carrier AAV by LC-MS/MS
AAV is widely used for efficient delivery of DNA payloads. The extent to which the AAV capsid can be used to deliver a protein payload is unexplored. Here, we report engineered AAV capsids that directly package proteins – Protein Carrier AAV (pcAAV). Nanobodies inserted into the interior of the caps...
ORGANISM(S): Adeno-associated virus 2 Srivastava/1982 
2025-05-07 | PXD054767 | Pride
Lc-msms Adeno-associated virus Dia Maxquant 
GenomicsRiboTag and bulk RNA sequencing using AAV-shGpr151 and AAV-shGpr151 with AAV-e5'UTR infected sensory neurons.
RiboTag and bulk RNA sequencing using AAV-shGpr151 and AAV-shGpr151 with AAV-e5'UTR infected sensory neurons.
PRJNA1284803 | ENA
TranscriptomicsmiRNA and mRNA expression profiling of hepatocellular carcinoma induced by AAV in vivo gene targeting at the Rian locus
This SuperSeries is composed of the following subset Series: GSE35402: miRNA expression profiling of hepatocellular carcinoma induced by AAV in vivo gene targeting at the Rian locus GSE35403: mRNA expression profiling of hepatocellular carcinoma induced by AAV in vivo gene targeting at the Rian locu...
ORGANISM(S): Mus musculus 
2012-07-02 | E-GEOD-35404 | biostudies-arrayexpress
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