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TranscriptomicsTime-course effect of APRIL on gene expression in HepG2 cells
APRIL (TNFSF13) is a ligand of the TNF superfamily which binds to two receptors, BCMA and TACI. We have found that APRIL and its receptor BCMA are specifically enhanced in hepatocellular carcinoma, as compared to non-cancerous liver tissue. We further identified that HepG2 cells present the same lig...
ORGANISM(S): Homo sapiens 
2011-05-20 | E-GEOD-29375 | biostudies-arrayexpress
ProteomicsMagnetic resonance imaging and transcriptome-proteome integration analysis demonstrate improved disease-outcome in the cuprizone mouse model following AAV-mediated delivery of A Proliferation Inducing Ligand
A Proliferation Inducing Ligand (APRIL) is a member of the tumour necrosis factor (TNF) superfamily and has recently been shown to modulate pro-inflammatory astrocyte responses, as well as to ameliorate disease outcome in the experimental autoimmune encephalomyelitis mouse model for multiple scleros...
ORGANISM(S): Mus musculus (Mouse) 
2025-11-10 | PXD056011 | Pride
Cuprizone Adeno-associated virus Neuroprotection Neuroinflammation Magnetic resonance imaging Transcriptomics Proteomics April 
GenomicsANRI HLA submissions April 2022 TT
ANRI HLA submissions April 2022 TT
PRJEB52229 | ENA
TranscriptomicsHigh contaminant loads in Lake Apopka mesocosms affect the ovarian transcriptome in largemouth bass [April]
Lake Apopka (Fl, USA) experienced heavy uses of organochlorine pesticides (OCPs) in the 1950s-1970 during an intense agricultural period. As a result, the region remains heavily contaminated and was declared a Superfund site by the US Environmental Protection Agency. Aquatic organisms inhabit the ...
ORGANISM(S): Micropterus salmoides 
2012-08-31 | E-GEOD-38738 | biostudies-arrayexpress
GenomicsEndogenous B cell TACI-Short-APRIL signaling
Endogenous B cell TACI-Short-APRIL signaling
PRJNA883412 | ENA
TranscriptomicsEndogenous B cell TACI-Short-APRIL signaling
Here we show that TACI-S increases its expression with maturation and colocalizes in the intracellular compartment with the ligand APRIL. APRIL downregulation in human B cells, eliminated class switch. These studies suggest the importance of intracellular APRIL together with TACI-S in maintaining hu...
ORGANISM(S): Homo sapiens 
2023-09-22 | GSE213981 | GEO
GenomicsMare Chiara Metagenome April 2014
A metagenome of the Mare Chiara LTER from April 2014
PRJEB6775 | ENA
TranscriptomicsCoreceptor delivery of paracrine APRIL to Golgic BCMA lowers immunogenicity of B-cell lymphoma
APRIL is involved in the development of B-cell lymphomas. However, in tumors the source of APRIL is paracrine while one signaling receptor, BCMA, is intracellular, raising the question on how APRIL may signal. In fact, tumor cells internalized APRIL via their surface HSPG. Then, APRIL trafficked int...
ORGANISM(S): Homo sapiens 
2018-04-26 | GSE113643 | GEO
TranscriptomicsBAFF and APRIL counterregulate susceptibility to inflammation-induced preterm birth
Emerging clinical evidence points to a function for B cell activating factor (BAFF) in pregnancy. However, a direct role for BAFF-axis members including BAFF, the closely related a proliferation-inducing ligand (APRIL), and their respective receptors in pregnancy has not been examined. This study de...
ORGANISM(S): Mus musculus 
2023-08-03 | GSE202811 | GEO
GenomicsBAFF and APRIL counterregulate susceptibility to inflammation-induced preterm birth
BAFF and APRIL counterregulate susceptibility to inflammation-induced preterm birth
PRJNA837296 | ENA
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