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ProteomicsMultiple sclerosis cuprizone mouse model and vitamin D supplementation
Dietary supplementation of vitamin D is commonly recommended to patients with multiple sclerosis (MS). We investigated the effect of 1,25-dihydroxyvitamin-D3 (1,25-(OH)2D3) on the brain proteome in the cuprizone model during remyelination. Mice were demyelinated with dietary cuprizone for 7 weeks. T...
ORGANISM(S): Mus musculus (Mouse) 
2017-08-16 | PXD002347 | Pride
Mouse Multiple sclerosis Vitamin d Cuprizone tmt 
ProteomicsMagnetic resonance imaging and transcriptome-proteome integration analysis demonstrate improved disease-outcome in the cuprizone mouse model following AAV-mediated delivery of A Proliferation Inducing Ligand
A Proliferation Inducing Ligand (APRIL) is a member of the tumour necrosis factor (TNF) superfamily and has recently been shown to modulate pro-inflammatory astrocyte responses, as well as to ameliorate disease outcome in the experimental autoimmune encephalomyelitis mouse model for multiple scleros...
ORGANISM(S): Mus musculus (Mouse) 
2025-11-10 | PXD056011 | Pride
Cuprizone Adeno-associated virus Neuroprotection Neuroinflammation Magnetic resonance imaging Transcriptomics Proteomics April 
TranscriptomicsExpression data from WT and TREM2 deficient microglia in response to cuprizone mediated demyelination
We examined the role of TREM2 on microglia responses to demyelination Microglia were FACS-purified from WT or Trem2-/- mice fed with 0.2% cuprizone diet.
ORGANISM(S): Mus musculus 
2015-04-22 | E-GEOD-66926 | biostudies-arrayexpress
ProteomicsBrain proteome analysis after 6 weeks of cuprizone or normal diet and 3 weeks of 40 Hz stimlation.
Brain proteome analysis after 6 weeks of cuprizone or normal diet and 3 weeks of 40 Hz stimlation or constant light and sound (control groups).
ORGANISM(S): Mus musculus (Mouse) 
2024-06-07 | PXD044572 | Pride
Cuprizone Mouse Tmt Genus 
ProteomicsMultiple sclerosis resaerch: EAE and cuprizone mouse brain TMT and label-free proteomics
Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system, and in this study we used quantitative proteomics to compare the brain proteomes of two MS mouse models, the immune-mediated experimental autoimmune encephalomyelitis (acute and recovery phase) and...
ORGANISM(S): Mus musculus (Mouse) 
2021-03-16 | PXD002318 | Pride
Orbitrap velos Mus musculus Brain Tmt Label-free 
GenomicsNeuron-specific RNA responses to EAE and cuprizone
Neuron-specific RNA responses to EAE and cuprizone
PRJNA1009857 | ENA
GenomicsMicroRNA expression in the cuprizone-induced demyelination mouse model
MicroRNA expression in the cuprizone-induced demyelination mouse model
PRJNA506487 | ENA
GenomicsGene expression profile in the cuprizone-induced demyelination mouse model
Gene expression profile in the cuprizone-induced demyelination mouse model
PRJNA529872 | ENA
ProteomicsDIA of Gasdermin-D knockout and cuprizone treated mouse brain tissue
Data-independent acquisition (DIA) of four replicates of mouse brain tissue lysate for each of the four conditions Gasdermin-D WT, Gasdermin-D KO, Gasdermin-D WT treated with cuprizone, and Gasdermin-D KO treated with cuprizone.
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2023-02-02 | MSV000091185 | MassIVE
GenomicsTranscriptomic profiling of oligodendrocytes, astrocytes, and microglia in a cuprizone-induced demyelination model
Transcriptomic profiling of oligodendrocytes, astrocytes, and microglia in a cuprizone-induced demyelination model
PRJNA1212138 | ENA
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