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ProteomicsVE-cadherin associated proteins in the absence of lncRNA LASSIE
The shear stress-regulated lncRNA LASSIE interacts with junctional proteins (e.g. PECAM-1, which interacts with VE-cadherin) and influences endothelial barrier function. Here we characterize the remodeling of the VE-Cadherin complex by the lncRNA LASSIE. LASSIE silenced HUVECs were subjected to co-i...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD018725 | Pride
Rna/protein interaction 
ProteomicsIdentification of protein interaction partners of the lncRNA Lassie
The shear stress-regulated lncRNA LASSIE interferes with endothelial cell function as knockdown of Lassie affects apoptosis, proliferation and angiogenic sprouting in vitro. RNA-antisense purification and subsequent mass spectrometry analysis identifed junctional proteins (such as PECAM-1) as intera...
ORGANISM(S): Homo sapiens (Human) 
2021-07-22 | PXD018724 | Pride
Rna/protein interaction 
ProteomicsIdentification of VE-cadherin associated proteins regulated through the lncRNA LASSIE
The shear stress-regulated lncRNA LASSIE interacts with cytoskeletal proteins as shown by RNA-antisense purification and subsequent mass spectrometry analysis using an anti-LASSIE and a non-targeting 3’ Desthiobiotin-TEG labeled 2’ O-Me-RNA. As this analysis resulted in high protein binding to the n...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD018734 | Pride
Rna/protein interaction 
ProteomicsIdentification of proteins that interact with the lncRNA Sarrah
Long non-coding RNAs (lncRNAs) contribute to (patho)physiological processes in the heart. Aging is the major risk factor for cardiovascular disease. Apoptosis of individual cardiomyocytes is one of the underlying causes for age-related cardiac dysfunction. Here, we identified the lncRNA Sarrah that ...
ORGANISM(S): Mus musculus (Mouse) 
2020-04-01 | PXD018315 | Pride
Rna/protein interaction 
ProteomicsKLF2-induced actin shear fibers control both alignment to flow and JNK signaling in vascular endothelium
The shear stress-induced transcription factor Krüppel-like factor 2 (KLF2) confers anti-inflammatory properties to endothelial cells through inhibition of activator protein 1, presumably by interfering with MAPK cascades. To gain insight into the regulation of these cascades by KLF2, we used antibo...
ORGANISM(S): Homo sapiens 
2010-06-25 | E-GEOD-19412 | biostudies-arrayexpress
TranscriptomicsHuman endothelial polyA+ RNA expression analysis
The human genome harbors a large number of sequences encoding for RNAs that are not translated but control cellular functions by distinct mechanisms. The expression and function of the longer transcripts namely the long non-coding RNAs (lncRNAs) in the vasculature is largely unknown. Here, we charac...
ORGANISM(S): Homo sapiens 
2014-03-19 | E-GEOD-54384 | biostudies-arrayexpress
TranscriptomicsMicroRNA-29 in Aortic Dilation: Implications for Aneurysm Formation
We compared the aorta of 6-weeks-old mice (young) with 18-months-old mice (old). Using the publicly available tools Sylamer and DIANA-mirExTra, we identified an enrichment for miR-29 binding sites in the 3'UTR of genes downregulated in the aged aortas. We subsequently showed that inhibition of miR-2...
ORGANISM(S): Mus musculus 
2011-10-13 | E-GEOD-32937 | biostudies-arrayexpress
TranscriptomicsMicroRNA-34a regulates cardiac ageing and function
We compared the heart of 6-weeks-old mice (young) with 18-months-old mice (old) hearts of 6 week old and 18 month old mice
ORGANISM(S): Mus musculus 
2013-02-20 | E-GEOD-43556 | biostudies-arrayexpress
UnknownTelemonitoring for heart failure: a meta-analysis.
Not available
S-EPMC10424885 | biostudies-literature
UnknownA scoping review on advancements in noninvasive wearable technology for heart failure management.
Not available
S-EPMC11470936 | biostudies-literature
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