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Proteomicsanalysis combined with fragment intensity predictions results in improved identification of classical bioactive peptides and sORF-encoded peptides
Bioactive peptides exhibit key roles in a wide variety of complex processes, such as regulation of body weight, learning, aging and innate immune response. Next to the classical bioactive peptides, emerging from larger precursor proteins by specific proteolytic processing, a new class of bio-active ...
ORGANISM(S): Mus musculus (Mouse) 
2021-10-11 | PXD026584 | Pride
Spectral intensity prediction Micropeptide Proteogenomics Neuropeptide Timstof Peptidomics Sorf-encoded peptide (sep) Non-coding 
ProteomicsAn mRNA-based workflow for validation of Neo-Epitope Presentation by HLA-I/Peptide Affinity Purification
Human leukocyte antigen (HLA) class I restricted neo-epitopes play a key role in inducing an adaptive cytotoxic T lymphocyte response against cancer. To enhance therapeutic and personalized cancer vaccination strategies, the identification of these cancer-specific neo-epitopes is essential. Current ...
ORGANISM(S): Homo sapiens (Human) 
2025-06-23 | PXD062551 | Pride
P53 epitope Hla-a*0201 Immunopeptidomics Mrna 
ProteomicsUltrafiltration and size exclusion chromatography combined with asymmetrical-flow field-flow fractionation for the isolation and characterisation of extracellular vesicles from urine
Extracellular vesicles (EVs) have a great potential in clinical applications, however their isolation from different body fluids and their characterisation are not yet optimal or standardised. Here we report the results of examining the performance of ultrafiltration combined with size exclusion chr...
ORGANISM(S): Homo sapiens (Human) 
2018-07-04 | PXD009709 | Pride
Urine Extracellular vesicle Exosome Orbitrap Lc-ms/ms 
ProteomicsSenolytics improve the neurogenic potential of non-glial progenitors and neurorepair in the dorsal pallium of aged killifish independent of inflammation
With advancing age, senescent cells accumulate as they are not efficiently cleared by the immune system anymore. Via a senescence-associated secretory phenotype, chronic senescent cells alter the microenvironment, creating an unfavorable milieu for neurogenesis and neurorepair. Using an innovative a...
ORGANISM(S): Nothobranchius furzeri 
2023-07-20 | PXD036437 | Pride
D+q Senolytics Neuroregeneration Senescent cells Neurorepair Aging N. furzeri 
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