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ProteomicsPhospho-docking protein 14-3-3 regulates microtubule-associated proteins in oocytes including the chromosomal passenger Borealin.
Global regulation of spindle-associated proteins is crucial in oocytes due to the absence of centrosomes and their very large cytoplasmic volume, but little is known about how this is achieved beyond involvement of the Ran-importin pathway. We previously uncovered a novel regulatory mechanism in Dr...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2022-05-04 | PXD030445 | Pride
Borealin. Oocytes Drosophila Microtubule-associated proteins 14-3-3 Quantitative proteomics Chromosomal passenger complex 
ProteomicsDirect Nucleosome Binding of Borealin Secures Chromosome Association of the Chromosomal Passenger Complex
CPC-NCP complexes were crosslinked using EDC and analysed by mass spectrometry. The results showed Borealin is critical for nucleosome binding made extensive contacts with NCPs, whereas Survivin interactions are mostly limited to the BIR domain and the H3 N-terminal tail as expected. Mapping the cro...
ORGANISM(S): Homo sapiens (Human) Xenopus laevis (African clawed frog) 
2019-09-30 | PXD012882 | Pride
Nucleosome core particles Chromosomal passenger complex Crosslinking 
UnknownRegulation of Borealin by phosphorylation at serine 219.
Not available
S-EPMC12392753 | biostudies-literature
UnknownMutations in BOREALIN cause thyroid dysgenesis.
Not available
S-EPMC6311960 | biostudies-literature
UnknownHepatic Loss of Borealin Impairs Postnatal Liver Development, Regeneration, and Hepatocarcinogenesis.
Not available
S-EPMC5076522 | biostudies-literature
UnknownBorealin/CDCA8 deficiency alters thyroid development and results in papillary tumor-like structures.
Not available
S-EPMC10641986 | biostudies-literature
UnknownBorealin-nucleosome interaction secures chromosome association of the chromosomal passenger complex.
Not available
S-EPMC6891087 | biostudies-literature
UnknownRanBP2 and SENP3 function in a mitotic SUMO2/3 conjugation-deconjugation cycle on Borealin.
Not available
S-EPMC2613119 | biostudies-literature
UnknownBorealin is repressed in response to p53/Rb signaling.
Not available
S-EPMC2112748 | biostudies-literature
UnknownBorealin Promotes Tumor Growth and Metastasis by Activating the Wnt/β-Catenin Signaling Pathway in Hepatocellular Carcinoma.
Not available
S-EPMC8926168 | biostudies-literature
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