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TranscriptomicsExpression data from primary bovine mammary epithelial cells (pbMEC) challenged with heat inactivated E. coli and S. aureus particles
Infections of the udder by Escherichia coli very often elicit acute inflammation, while Staphylococcus aureus infections tend to cause mild, subclinical inflammation and persistent infections. The molecular causes undercovering the different disease patterns are poorly understood. We therefore profi...
ORGANISM(S): Bos taurus 
2012-09-07 | E-GEOD-25413 | biostudies-arrayexpress
TranscriptomicsExpression data from primary bovine mammary epithelial cells (pbMEC) primed with 100 ng/ml LPS and subsequently challenged with heat inactivated E. coli particles after a short or long waiting period
Background: Udder infections with environmental pathogens like Escherichia coli are a serious problem for the diary industry. Reduction of incidence and severity of mastitis is desirable and mild priming of the immune system either through vaccination or with low doses of an immune stimulant like l...
ORGANISM(S): Bos taurus 
2014-09-13 | E-GEOD-32186 | biostudies-arrayexpress
TranscriptomicsPiwi proteins and piRNAs in mammalian oocytes and early embryos
Germ cells of most animals critically depend on piRNAs and Piwi proteins. Surprisingly, piRNAs in mouse oocytes are relatively rare and dispensable. We present compelling evidence for strong Piwi-piRNA expression in oocytes of other mammals. Human fetal oocytes express PIWIL2 and transposon-enriched...
ORGANISM(S): Macaca fascicularis 
2015-03-27 | E-GEOD-64942 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of primary human astrocytes from brain treated by stathmin, poly IC and ultrapure LPS to examine the effects of different Toll-like receptor agonists
Goal of the experiment was to examine the effects of different Toll-like receptor agonists on the human astrocyte response, in termsof levels of transcripts encoding cytokines, chemokines and theirreceptors. Stathmin and poly IC are considered as agonist for TLR3, LPSas an agonist for TLR4. The manu...
ORGANISM(S): Homo sapiens 
2010-02-11 | E-TABM-851 | biostudies-arrayexpress
ProteomicsHuman dental calculus LC-MS/MS
The purpose of this study was to investigate oral microbiome and host proteins in archaeological human dental tissues using a shotgun proteomics approach. The research focuses on dental calculus (mineralized plaque), dentine, a carious lesion, and an alveolar bone abscess from the medieval site of D...
ORGANISM(S): Bos Taurus (ncbitaxon:9913) Homo Sapiens (ncbitaxon:9606) Ovis (ncbitaxon:9935) 
2016-10-23 | MSV000080279 | MassIVE
TranscriptomicsComparison of hepatocarcinogen-induced gene expression profiles in conventional primary rat hepatocytes with in vivo rat liver
At present, substantial efforts are focused on the development of in vitro assays coupled with M-bM-^@M-^]omicsM-bM-^@M-^] technologies for the identification of carcinogenic substances as an alternative to the classical 2-year rodent carcinogenicity bioassay. A prerequisite for the eventual regulat...
ORGANISM(S): Rattus norvegicus 
2012-04-23 | E-GEOD-36524 | biostudies-arrayexpress
TranscriptomicsHost cell tropism of Propionibacterium acnes: infection scenarios differ on skin and prostate epithelia
Proprionibacterium acnes is a Gram positive bacterium found ubiquitously on human skin, where it is typically considered to assume a commensal relationship with its host. However, it is also closely associated with the skin condition acne vulgaris. More controversially, it has a postulated involveme...
ORGANISM(S): Homo sapiens 
2012-11-21 | E-GEOD-33731 | biostudies-arrayexpress
TranscriptomicsAnalyses of transcriptomic responses generated by hepatocarcinogens in a battery of liver-based in vitro models
For assessing the cancer-causing potential for humans of a chemical compound, the conventional approach is the use of the 2-year rodent carcinogenicity bioassay, thus alternatives such as in vitro toxicogenomics are highly desired. In the present study, the transcriptomics responses following exposu...
ORGANISM(S): Rattus norvegicus 
2013-02-20 | E-GEOD-40117 | biostudies-arrayexpress
Genomicsena-DATASET-UMCU-10-10-2018-09:56:24:582-1061 - samples
WGS of ovarian cancer organoids, tumor samples and blood references. Ovarian cancer (OC) is a heterogeneous disease usually diagnosed at a late stage. Experimental in vitro models that faithfully capture the hallmarks and tumor heterogeneity of OC are limited and hard to establish. We present a nove...
EGAD00001004387 | EGA
Genomicsena-DATASET-UMCU-04-11-2019-12:52:17:220-46 - samples
WGS Nanopore nanopore sequencing of organoid line HGS-3.1 and matching blood reference HGS-3
EGAD00001005476 | EGA
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