Sort   by:  
 Page size 
ProteomicsTop-down proteome of de-fatted Bos taurus milk from an animal with clinical mastitis
Quarter-milk samples were collected from a cow with clinical mastitis on day 13 and day 16 postpartum. Milk was collected from a clinical quarter with signs of abnormality (i.e., flakes, clots, blood) and one normal quarter of the same animal. Milk samples were processed with the MPLEx protocol (ht...
ORGANISM(S): Bos Taurus (ncbitaxon:9913) 
2022-02-09 | MSV000088805 | MassIVE
TranscriptomicsAsymmetric cancer cell division regulated by AKT, Reactive Oxygen Species (ROS) high versus ROS low mRNA
Human tumors often contain slowly proliferating cancer cells that resist treatment but we do not know precisely how these cells arise. We show that rapidly proliferating cancer cells can divide asymmetrically to produce slowly proliferating “G0-like” progeny that are enriched following chemotherapy ...
ORGANISM(S): Homo sapiens 
2011-07-14 | E-GEOD-30465 | biostudies-arrayexpress
MetabolomicsGNPS - Effect of rumen-protected methionine on metabolic profile in liver, muscle and blood serum samples of growing German Simmental bulls at restricted protein supply
This study aimed to determine the metabolic response of growing Fleckvieh bulls fed diets low in crude protein (CP) supplemented with rumen-protected methionine (RPM). In total, 69 bulls were assigned to three dietary treatments (n=23/group): Positive control (CON; 13.7% CP; 2.11 g methionine/kg DM...
ORGANISM(S): Bos Taurus (ncbitaxon:9913) 
2023-07-07 | MSV000092367 | GNPS
ProteomicsAn INS-1 𝛽-cell proteome highlights the role of fatty acid biosynthesis in glucose-stimulated insulin secretion
Pancreatic beta cells secrete insulin as a response to rising glucose levels in the blood, a process that is known as glucose-stimulated insulin secretion (GSIS). Although GSIS has been extensively studied, not all associated mechanisms are fully understood at the molecular level. In this study, we ...
ORGANISM(S): Rattus norvegicus (Rat) 
2025-07-07 | PXD053750 | Pride
Beta cells Insulin secretion Glucose stimulation Quantitative proteomics 
ProteomicsEffect of rumen-protected methionine on metabolic profile in liver, muscle and blood serum samples of growing German Simmental bulls at restricted protein supply
This study aimed to determine the metabolic response of growing Fleckvieh bulls fed diets low in crude protein (CP) supplemented with rumen-protected methionine (RPM). In total, 69 bulls were assigned to three dietary treatments (n=23/group): Positive control (CON; 13.7% CP; 2.11 g methionine/kg DM...
ORGANISM(S): Bos Taurus (ncbitaxon:9913) 
2023-07-07 | MSV000092367 | MassIVE
ProteomicsTDFragMapper: Evaluating experimental parameters for confident intact protein characterization in top-down proteomics
New software-tool allowing an easy visualization of fragment ions and thus a rapid evaluation of key experimental parameters on the sequence coverage obtained for the MS/MS analysis of intact proteins. Our tool can deal with multiple fragmentation methods. We demonstrate that TDFragMapper can rapidl...
ORGANISM(S): Bos taurus (Bovine) Homo sapiens (Human) Streptococcus dysgalactiae Escherichia coli 
2021-12-30 | PXD024643 | Pride
Visualization tool Top-down proteomics Lc-ms/ms 
ProteomicsIntact extracellular vesicle cross-linking on vesicles derived from MDA-MB-231 and LM2 cells
The development of any pharmaceutical requires characterization of the compound, usually be several techniques. Therefore, characterizing the protein content and biochemical state of EVs is of great importance for their useif they are to be used as biopharmaceuticals. Structural characterization of ...
ORGANISM(S): Homo sapiens (Human) 
2022-11-08 | PXD029591 | Pride
Tnbc Evs Xl-ms Structural proteomics Cx-ms 
ProteomicsA framework for quality control in quantitative proteomics
A thorough evaluation of the quality, reproducibility, and variability of bottom-up proteomics data is necessary at every stage of a workflow, from planning to analysis. We share vignettes applying adaptable quality control (QC) measures to assess sample preparation, system function, and quantitativ...
ORGANISM(S): Homo Sapiens Mus Musculus Bos Taurus Saccharomyces Cerevisiae 
2024-10-01 | PXD051318 | panorama
UnknownEffects of icosapent ethyl according to baseline residual risk in patients with atherosclerotic cardiovascular disease: results from REDUCE-IT.
Not available
S-EPMC11873788 | biostudies-literature
UnknownMapping the human genetic architecture of COVID-19.
Not available
S-EPMC8674144 | biostudies-literature
Sort   by:  
 Page size