Sort   by:  
 Page size 
TranscriptomicsCDK inhibitors and flavopiridol profiling on A2780 and MCF7 cells
This SuperSeries is composed of the following subset Series: GSE18486: CDK inhibitors PHA-848125 and PHA-690509 profiling on A2780 GSE18498: CDK inhibitor PHA-793887 profiling on A2780 GSE18501: CDK inhibitor PHA-848125 gene expression profiling on MCF7 cell line GSE18504: Flavopiridol profiling on ...
ORGANISM(S): Homo sapiens 
2010-07-14 | E-GEOD-18552 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human A2780 ovarian cancer cell lines treated (TRT) with two compounds (A and B) vs. untreated (CTRL) sampled at 6 different time points and processed on different days to summarize probe levels of Affymetrix arrays taking into account day-to-day variability
Day-to-day variability in microarray experiments is a recognized source of variation that can impede the analysis of large microarray studies where samples are processed on different days. In this study, we have applied an algorithm, called D2Dsum, which is based on a log-linear fixed effect model t...
ORGANISM(S): Homo sapiens 
2008-06-17 | E-GEOD-9826 | biostudies-arrayexpress
TranscriptomicsCDK inhibitor PHA-848125 gene expression profiling on MCF7 cell line
The effects of the CDK inhibitor PHA-848125 (referred to as CDK-125) on the MCF7 human adenocarcinoma mammary cell line were analysed by gene expression profiling. The MCF7 cell line was treated with PHA-848125 for 6 hours at a dose equal to 5 times the IC50. Untreated MCF7 cells were used as a con...
ORGANISM(S): Homo sapiens 
2010-07-14 | E-GEOD-18501 | biostudies-arrayexpress
TranscriptomicsCompounds profiling on MCF7
The effects of several compounds on the MCF7 human adenocarcinoma mammary cell line were analysed by gene expression profiling. Tested compounds: HSP90 inhibitors: 17AAG (Tanespimycin), NVP-AUY922, NMS-E973 (cpd developed at NMS). CDK inhibitors: CDK-887 (cpd developed at NMS). Topoisomerase inhibi...
ORGANISM(S): Homo sapiens 
2010-07-14 | E-GEOD-19638 | biostudies-arrayexpress
TranscriptomicsCDK inhibitor PHA-793887 profiling on A2780
The effects of the CDK inhibitor PHA-793887 on the A2780 human adenocarcinoma ovary cell line were analysed by gene expression profiling. The A2780 cell line was treated with PHA-793887 (CDK-887) for 6 hours at a dose equal to 5 time the IC50. Untreated A2780 cells were used as a control. Two replic...
ORGANISM(S): Homo sapiens 
2010-07-14 | E-GEOD-18498 | biostudies-arrayexpress
TranscriptomicsFlavopiridol profiling on A2780
The effects of the CDK inhibitor Flavopiridol on the A2780 human adenocarcinoma ovary cell line were analysed by gene expression profiling. A2780 cells were treated with Flavopiridol for 6 hours at a dose equal to 5 times the IC50. Untreated A2780 cells were used as a control. Two replicates per tre...
ORGANISM(S): Homo sapiens 
2010-07-14 | E-GEOD-18504 | biostudies-arrayexpress
TranscriptomicsCDK inhibitors PHA-848125 and PHA-690509 profiling on A2780
The effects of the CDK inhibitors PHA-848125 and PHA-690509 on the A2780 cell line were analysed by gene expression profiling. The A2780 cell line was treated with PHA-848125 (CDk-125) or PHA-690509 (CDk-509) for 6 hours at a dose equal to 5 times the IC50. Untreated A2780 cells were used as a contr...
ORGANISM(S): Homo sapiens 
2010-07-14 | E-GEOD-18486 | biostudies-arrayexpress
TranscriptomicsTranscriptional analysis of an E2F gene signature as a biomarker of activity of the cyclin-dependent kinase inhibitor PHA-793887 in tumor and skin biopsies from a phase I clinical study
Microarray analysis of transcriptional changes in biopsies of solid tumors from patients treated in a Phase I study with the Cdk inhibitor PHA-793887. 7 patient biopsies pre- and post-treatment in dye swap. Tumors are of different origins, and are described in the accompanying manuscript.
ORGANISM(S): Homo sapiens 
2010-05-28 | E-GEOD-18553 | biostudies-arrayexpress
TranscriptomicsTranscriptional pathway signatures for the Aurora inhibitor Danusertib
Treatment with Aurora inhibitors has been shown to induce diverse biological responses in different tumor cell lines, in part depending on their p53 status. To characterize at the transcriptional level the effects of Danusertib we analyzed by microarray different tumor cell lines, with WT or mutant ...
ORGANISM(S): Homo sapiens 
2011-09-19 | E-GEOD-24547 | biostudies-arrayexpress
Sort   by:  
 Page size