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The paired-end next-generation sequencing of all small RNAs of less than 200 nucleotides in length from four different human cell lines (SKOV3ip1, MCF-7, BJ-Tielf, INOF) allowed us to determine the exact sequence(s) and variations of human box C/D snoRNAs (small nucleolar RNAs), revealing processing...
ORGANISM(S): Homo sapiens 
NOPCHAP1 is a PAQosome cofactor that helps loading NOP58 on RUVBL1/2 during box C/D snoRNP biogenesis
Eukaryotic ribosome synthesis is a highly complex, multistep process that is best characterized in the yeast Saccharomyces cerevisiae. It is orchestrated by over 200 ribosome assembly factors and 75 small nucleolar ribonucleoproteins (snoRNPs), which guide site-specific chemical modifications of pre...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2026-01-30 | PXD067909 | Pride
Biogenesis of eukaryotic box C/D snoRNPs initiates co-transcriptionally and requires the action of an assembly machinery including the HSP90/R2TP complex, Rsa1p:Hit1p (NUFIP1:ZNHIT3 in human) heterodimer and the Bcd1 protein (ZNHIT6 in human). We identified genetic interactions between the Rsa1p-enc...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2021-02-22 | PXD023434 | Pride
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