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TranscriptomicsExpression changes in Caenorhabditis elegans xpa-1 mutant
Background: The ability of an organism to repair DNA damage is implicated in carcinogenesis and aging. Interestingly expression profiling of Nucleotide Excision Repair (NER) deficient segmental progeroid mice revealed gene expression changes resembling these observed in aged wild type animals. Our p...
ORGANISM(S): Caenorhabditis elegans 
2013-05-03 | E-GEOD-39252 | biostudies-arrayexpress
TranscriptomicsHistone H3 lysine 4 acetylation-methylation dynamics define breast cancer subtypes [RNA-seq]
The onset and progression of breast cancer are linked to genetic and epigenetic changes that alter the normal programming of cells. Epigenetic modifications of DNA and histones contribute to chromatin structure that results in the activation or repression of gene expression. Several epigenetic pathw...
ORGANISM(S): Homo sapiens 
2016-02-10 | E-GEOD-75168 | biostudies-arrayexpress
GenomicsHistone H3 Lysine4 Acetylation-Methylation Dynamics Define Breast Cancer Subtypes [ChIP-seq]
The molecular signature at histone H3K4 involved in epigenetic regulation of normal (MCF10A) and transformed (MCF7, MDA-MB-231) breast cells using ChIP-Seq technology. This study examines the dynamic distribution of H3K4me3 and H3K4ac histone modification associated with active chromatin to provide...
ORGANISM(S): Homo sapiens 
2016-02-10 | E-GEOD-69377 | biostudies-arrayexpress
GenomicsHistone H3 Lysine4 Acetylation-Methylation Dynamics Define Breast Cancer Subtypes
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2016-02-10 | E-GEOD-75169 | biostudies-arrayexpress
TranscriptomicsTri-KIX +/- c-Myb MEFs
Transcription profiling by array of wild type and p300 KIX/KIX; CBP +/KIX primary mouse embryonic fibroblasts (MEFs) transduced with either MSCV-c-Myb_IRES-GFP or MSCV-IRES-GFP retrovirus to determine the effect of mutating the KIX domain of CBP and p300 on c-Myb regulated gene expression. CBP KIX ...
ORGANISM(S): Mus musculus 
2014-02-10 | E-MTAB-1973 | biostudies-arrayexpress
no omics definedGenotyping of twenty Pseudomonas aeruginosa strains
20 P. aeruginosa strains were genotyped using a custom spotted oligo array (Ausubel P. aruginosa genotyping 4.8K v1), which included primarily oligos for genes present in strain PA14 but absent in PAO1, and oligos for genes present in PAO1 but absent in PA14 (as well as controls).
ORGANISM(S): Pseudomonas aeruginosa 
2006-10-06 | E-MEXP-824 | biostudies-arrayexpress
TranscriptomicsFACS-sorted Pancreatic Adenocarcinoma for Molecular Profiling
Frozen, whole tissue was dissociated and sorted into to tumor and stromal fractions via FACS Keywords: Mapping Array Profiling of tumor and stromal fractions from whole tissue
ORGANISM(S): Homo sapiens 
2010-02-18 | E-GEOD-14579 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of human MCF10A cells reveal changes upon expression of activated versions of MEK1 and HRAS
MCF10A cells were then transfected with MEK1(S217S221), HRAS(G12V), and null control vectors; Cells were lysed 24 hours post-transfection with collection of total RNA and protein Experiment Overall Design: Overexpression of Oncogenic protein was confirmed via Western blot
ORGANISM(S): Homo sapiens 
2009-01-17 | E-GEOD-12764 | biostudies-arrayexpress
TranscriptomicsGene expression data from human metastatic melanoma tumors that may predict response to RAF265
To determine how mutation of BRAF affected the response to RAF265, we utilized a tumor orthotopic implant model of early passage melanoma tumors in nude mice from a series of 17 patients with advanced metastatic Tumor growth was compared between RAF265 treatment (40 mg/kg, QD) and diluent control gr...
ORGANISM(S): Homo sapiens 
2012-05-01 | E-GEOD-30812 | biostudies-arrayexpress
TranscriptomicsTri-KIX_DP_thymocytes
To determine the effect of mutation of the KIX domain of CBP and p300 on gene expression, thymuses dissected from four to seven week old wild type and CBP KIX/KIX;p300 +/KIX adult mice were dissociated into single cell suspesions, antibody stained for CD4 and CD8, sorted for CD4+ CD8+ double positiv...
ORGANISM(S): Mus musculus 
2014-02-10 | E-MTAB-1974 | biostudies-arrayexpress
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