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TranscriptomicsBPTF is required for c-MYC-induced remodelling of target chromatin and transcriptional activation [RNA-Seq]
The c-MYC oncogene is a key transcription factor deregulated in most human tumors. Histone marks associated with transcriptionally active genes in euchromatic islands define the set of high-affinity c-MYC targets. The mechanisms involved in their recognition by c-MYC are not known but likely involve...
ORGANISM(S): Homo sapiens 
2016-01-19 | E-GEOD-65545 | biostudies-arrayexpress
GenomicsBPTF is required for c-MYC-induced remodelling of target chromatin and transcriptional activation [ChIP-Seq]
The c-MYC oncogene is a key transcription factor deregulated in most human tumors. Histone marks associated with transcriptionally active genes in euchromatic islands define the set of high-affinity c-MYC targets. The mechanisms involved in their recognition by c-MYC are not known but likely involve...
ORGANISM(S): Homo sapiens 
2016-01-19 | E-GEOD-65544 | biostudies-arrayexpress
GenomicsAltererythrobacter insulae strain:BPTF-M16
Altererythrobacter insulae strain:BPTF-M16 Genome sequencing and assembly
PRJNA482751 | ENA
ProteomicsMass spectrometry-based validation of BPTF knockout in human induced pluripotent stem cells 
We generated a BPTF knockout human induced pluripotent stem cell (iPSC) line using CRISPR-Cas9 and confirmed loss of the targeted locus by genotyping. Quantitative mass spectrometry verified complete absence of BPTF protein in the knockout clone. This validated line was used for downstream functiona...
ORGANISM(S): Homo sapiens (Human) 
2026-08-07 | PXD068407 | Pride
Stem cells Bptf Knockout Ipscs 
GenomicsTranscriptomic analysis of Bptf wild-type and Bptf heterozygous lymphomas arising from Em-Myc tumors
Transcriptomic analysis of Bptf wild-type and Bptf heterozygous lymphomas arising from Em-Myc tumors
PRJNA594301 | ENA
GenomicsBPTF is essential for murine neocortical development
BPTF is essential for murine neocortical development
PRJNA647223 | ENA
ProteomicsThe alternative Nucleosome Remodeling Factor complex sustains acute myeloid leukemia by regulating the accessibility of insulator regions
Efficient treatment of Acute Myeloid Leukemia (AML) patients remains a challenge despite recent advances. Here using a CRISPRi screen targeting chromatin factors, we identified BPTF as an essential regulator of AML cell survival. We demonstrate that BPTF forms an alternative NURF chromatin remodelin...
ORGANISM(S): Homo sapiens (Human) 
2023-11-12 | PXD044656 | Pride
Bptf Human Aml 
GenomicsBPTF is required for c-MYC-induced remodelling of target chromatin and transcriptional activation
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2016-01-19 | E-GEOD-65546 | biostudies-arrayexpress
UnknownBPTF Is Essential for T Cell Homeostasis and Function.
Not available
S-EPMC5127169 | biostudies-literature
GenomicsBPTF regulstes androgen receptor activity by enhancing chromatin accessibility and stabilizing the AR-FOXA1 interaction
BPTF regulstes androgen receptor activity by enhancing chromatin accessibility and stabilizing the AR-FOXA1 interaction
PRJNA1215275 | ENA
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