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TranscriptomicsGlucose-depletion time-course experiment in Saccharomyces cerevisiae wild-type cells.
To investigate the glucose regulatory system in Saccharomyces cerevisiae, we conducted a time-course in which glucose-depleted wildtype (WT) cells were inoculated into fresh media (SC, 2% glucose). Their subsequent transcriptional output was monitored over a period of five hours by DNA microarrays: ...
ORGANISM(S): Saccharomyces cerevisiae 
2012-06-17 | E-GEOD-33098 | biostudies-arrayexpress
TranscriptomicsDeletion mutant analysis of established glucose signaling and metabolic pathway members in Saccharomyces cerevisiae
To understand the organisation of the glucose regulatory system, we analysed 91 deletion mutants of established glucose signalling and metabolic pathway members in Saccharomyces cerevisiae by DNA microarrays. These deletion mutants do not induce pathway-specific transcriptional responses reflecting ...
ORGANISM(S): Saccharomyces cerevisiae 
2012-06-17 | E-GEOD-33097 | biostudies-arrayexpress
TranscriptomicsSlx5_Slx8_Genome_Stability
The Saccharomyces cerevisiae Slx5/8 complex is the founding member of a recently defined class of ubiquitin ligases (STUbLs) that target sumoylated substrates. Slx5/8 has been implicated in genome stability and transcription, but the precise contribution to these processes is not clear. To character...
ORGANISM(S): Saccharomyces cerevisiae 
2013-08-06 | E-GEOD-33929 | biostudies-arrayexpress
TranscriptomicsGene deletion expression profiles of yeast chromatin modifiers
Packaging of DNA into chromatin has a profound impact on gene expression. To understand how changes in chromatin influence transcription, we analyzed 165 mutants of chromatin machinery components in Saccharomyces cerevisiae. mRNA expression patterns change in 80% of mutants, always with specific eff...
ORGANISM(S): Saccharomyces cerevisiae 
2011-05-23 | E-GEOD-25909 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of yeast deletion mutants of putative protein complex members
A number of putative protein complexes have been selected for experimental validation by gene expression profiling of the individual deletion mutants of the respective protein complex members.
ORGANISM(S): Saccharomyces cerevisiae 
2010-06-01 | E-TABM-654 | biostudies-arrayexpress
TranscriptomicsExpression profiling of yeast kinase and phosphatase knockouts
To understand relationships between phosphorylation-based signaling pathways, we analyzed 150 deletion mutants of protein kinases and phosphatases in S. cerevisiae using DNA microarrays. Downstream changes in gene expression were treated as a phenotypic readout. Double mutants with synthetic genetic...
ORGANISM(S): Saccharomyces cerevisiae 
2010-12-09 | E-GEOD-25644 | biostudies-arrayexpress
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