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Despite recent advances in the management of BRCA1 mutated high-grade serous ovarian cancer (HGSC), the physiology of these tumors remains poorly understood. Here we provide a comprehensive molecular understanding of the signaling processes that drive HGSC pathogenesis and their dependency on BRCA1 ...
ORGANISM(S): Homo sapiens (Human) 
2022-04-04 | PXD020271 | Pride
High-grade serous carcinoma (HGSC) is the most common and deadly subtype of ovarian cancer. Although most patients will initially respond to first-line treatment with a combination of surgery and platinum-based chemotherapy, up to a quarter will be resistant to treatment. We aimed to identify a new ...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD035084 | Pride
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