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TranscriptomicsBRAF Mutation Is Rare in Advanced-Stage Low-Grade Ovarian Serous Carcinomas
Low-grade ovarian serous carcinomas are believed to arise via an adenoma-serous borderline tumor-serous carcinoma sequence. In this study, we found that advanced-stage, low-grade ovarian serous carcinomas both with and without adjacent serous borderline tumor shared similar regions of loss of hetero...
ORGANISM(S): Homo sapiens 
2011-03-04 | E-GEOD-27659 | biostudies-arrayexpress
TranscriptomicsBRAF Mutation, NRAS Mutation, and the Absence of an Immune-Related Expressed Gene Profile Predict Poor Outcome in Patients with Stage III Melanoma
Prediction of outcome for melanoma patients with surgically-resected macroscopic nodal metastases is very imprecise. We performed a comprehensive clinicopathologic assessment of fresh-frozen macroscopic nodal metastases and the preceding primary melanoma, somatic mutation profiling and gene expressi...
ORGANISM(S): Homo sapiens 
2013-12-10 | E-GEOD-53118 | biostudies-arrayexpress
TranscriptomicsHuman BRAF-V600E melanoma cell lines drug sensitive vs drug resistant
aCGH of human melanoma cell lines comparing parental (drug sensitve) vs isogenic drug resistant-derived subline Two condition experiment: two BRAF-V600E mutant cell lines (drug sensitive - parental baseline) vs two derived sublines after chronic exposure to the MEK inhibitor trametinib (drug resista...
ORGANISM(S): Homo sapiens 
2014-04-21 | E-GEOD-49430 | biostudies-arrayexpress
TranscriptomicsAnti-BRAF mutation drug resistance enhances EGFR expression in melanomas [methylation profiling]
We treated melanoma cells with BRAF mutation with BRAF inhibitor and screened for BRAF inhibitor resistant cells. We extracted DNA from parental cells and resistant cell lines. We compared the DNA methylation via Illumina 450K Methylation Array Bisulphite converted DNA from the 4 specimens was hybr...
ORGANISM(S): Homo sapiens 
2014-12-17 | E-GEOD-45647 | biostudies-arrayexpress
TranscriptomicsAnti-BRAF mutation drug resistance enhances EGFR expression in melanomas [expression profiling]
We treated melanoma cells with BRAF mutation with BRAF inhibitor and screened for BRAF inhibitor resistant cells. We extracted total mRNA from parental cells and resistant cell lines. We compared their expression by carried out Affymetrix Huex 1.0 ST expression array. Two paired parental/derived ce...
ORGANISM(S): Homo sapiens 
2014-12-17 | E-GEOD-45648 | biostudies-arrayexpress
ProteomicsBRAF complexes - Discrete cytosolic macromolecular BRAF complexes exhibit distinct activities and composition
BRAF interactomes dependent on the mutation V600E are analyzed by SEC-PCP-SILAC and HA-IPs comparing V600E to WT
ORGANISM(S): Homo sapiens (Human) 
2017-01-03 | PXD004585 | Pride
Ap-ms V600e Sec-pcp-silac Caco2 cells Braf Lc-ms/ms 
ProteomicsSingle-vesicle heterogeneity and uptake of extracellular vesicles affected by oncogenic KRAS and BRAF revealed by proteomics and nano-flow cytometry
This study explores the effects of KRAS and BRAF mutations on the heterogeneity, distribution, and uptake of extracellular vesicles (EVs), with a focus on their role in cancer biology and therapeutic potential. Nine cancer cell lines, including colorectal (Caco-2, HT29, WiDr, HCT116, LoVo) and lung ...
ORGANISM(S): Homo sapiens (Human) 
2026-08-31 | PXD062280 | Pride
Braf mutation Extracellular vesicles Kras mutation Lung cancer Colorectal cancer 
TranscriptomicsOncogenic BRAF regulates oxidative metabolism via PGC1alpha and MITF
We evaluated two matched human cell lines derived from primary melanocytes, termed pmel+BRAF(V600E) and pmel+BRAF(V600E)+MITF. These cells are therefore isogenic with the exception of the expression of MITF. Gene Set Enrichment Analysis of microarray data identified a highly significant induction of...
ORGANISM(S): Homo sapiens 
2013-03-07 | E-GEOD-38007 | biostudies-arrayexpress
ProteomicsBRAF inhibitors enhance erythropoiesis and treat anemia through paradoxical activation of MAPK
Erythropoiesis is a crucial part in hematopoietic system, while facing disruptions from various diseases conditions. Anemia and blood shortages has become global challenges, with current finite pharmacological options like EPO or glucocorticoids having limitations, especially in genetic anemias like...
ORGANISM(S): Homo Sapiens 
2024-09-09 | PXD055730 |
TranscriptomicsSpectrum, clinical correlates and clinical implications of BRAF-inhibitor resistance mechanisms in melanoma
Multiple BRAF inhibitor resistance mechanisms have been described, however their relative frequency, clinical correlates, and effect on subsequent therapy have not been assessed in patients with metastatic melanoma. Excised progressing BRAFV600 mutant melanoma metastases (Prog) from patients treated...
ORGANISM(S): Homo sapiens 
2014-02-19 | E-GEOD-50509 | biostudies-arrayexpress
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