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MetabolomicsChanges in lipid profiles of epileptic mouse model

INTRODUCTION: Approximately 1% of the world's population is impacted by epilepsy, a chronic neurological disorder characterized by seizures. One-third of epileptic patients are resistant to AEDs, or have medically refractory epilepsy (MRE). One non-invasive treatment that exists...

2022-01-06 | MTBLS1432 | MetaboLights
UnknownStabilization of O-O Bonds by d0 Cations in Li4+ xNi1- xWO6 (0 ≤ x ≤ 0.25) Rock Salt Oxides as the Origin of Large Voltage Hysteresis.
Not available
S-EPMC7007214 | biostudies-literature
Proteomics40S hnRNP particles are a novel class of nuclear biomolecular condensates
Heterogenous nuclear ribonucleoproteins (hnRNPs) are abundant proteins implicated in various steps of RNA processing that assemble on nuclear RNA into larger complexes termed 40S hnRNP particles. Despite their initial discovery 55 years ago, our understanding of these intriguing macromolecular assem...
ORGANISM(S): Homo sapiens (Human) 
2022-05-30 | PXD031677 | Pride
Hnrnp Ribonucleosome 40s particles 
ProteomicsRadioproteomics stratifies molecular response to antifibrotic treatment in pulmonary fibrosis
Antifibrotic therapy with nintedanib is the clinical mainstay in the treatment of progressive fibrosing interstitial lung disease (ILD). High-dimensional medical image analysis, known as radiomics, provides quantitative insights into organ-scale pathophysiology, generating digital disease fingerprin...
ORGANISM(S): Mus musculus (Mouse) 
2024-10-17 | PXD052594 | Pride
Interstitial lung disease Radiomics Proteomics Multiomics Imaging Lung fibrosis Nintedanib 
TranscriptomicsA combinatorial extracellular matrix platform identifies cell-extracellular matrix interactions that correlate with metastasis
Extracellular matrix interactions play essential roles in normal physiology and many pathological processes. Here, we report a novel screening platform capable of measuring phenotypic responses to combinations of ECM molecules. While the importance of ECM interactions in metastasis is well documente...
ORGANISM(S): Mus musculus 
2012-10-11 | E-GEOD-40222 | biostudies-arrayexpress
ProteomicsInhibition of nonsense-mediated mRNA decay reduces the tumorigenicity of human fibrosarcoma cells
Nonsense-mediated mRNA decay (NMD) is a eukaryotic RNA degradation pathway that targets for degradation faulty mRNAs with premature termination codons as well as many physiological mRNAs encoding full-length proteins. Consequently, NMD functions in both, quality control and post-transcriptional regu...
ORGANISM(S): Homo sapiens (Human) 
2023-09-19 | PXD041853 | Pride
Smg7 Nmd Cell migration Fibrosarcoma Tumor progression 
ProteomicsCharacterisation of the Semliki Forest Virus-host cell interactome reveals the viral capsid protein as an inhibitor of nonsense-mediated mRNA decay
Understanding the complex interactions between the viral and the host cell proteins is crucial for elucidating the mechanisms underlying successful virus replication strategies and for developing specific antiviral interventions. This project presents the first comprehensive protein-protein interact...
ORGANISM(S): Homo sapiens (Human) Semliki Forest virus 
2021-05-07 | PXD022036 | Pride
Semliki forest virus  sfv  capsid  sirna screen  alphavirus  rna virus  nmd  virus-host protein interactions Nonsense-mediated mrna decay 
UnknownCharacterization of a large cluster of HIV-1 A1 infections detected in Portugal and connected to several Western European countries.
Not available
S-EPMC6510806 | biostudies-literature
MetabolomicsGNPS - Brain energy metabolism adenosine mediated cAMP signaling in astrocytes.
Whole brain mouse central carbon targeted LCMS metabolomics.
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2024-04-01 | MSV000094445 | GNPS
ProteomicsMemo1 promotes FGF23-driven signaling by oxidative modulation of small Rho-GTPases and protein tyrosine phosphatase activity
Memo is a copper-dependent redox enzyme modulating receptor tyrosine kinase signaling by unknown mechanisms (Meira et al., Nat Cell Biol 2004; MacDonald et al., Science Signal 2014). Memo1 deletion causes a phenotype partially resembling Klotho and Fgf23-deficient mice (Haenzi et al., FASEB J 2014; ...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD022382 | Pride
Arhgdia Rhogdi1 Redox signaling Memo1 Cysteine oxidation 
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