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MetabolomicsMicrobiota-derived p-cresol and indole metabolites mediates neurotoxic gut-brain axis dysregulation in ALS
Integrated metabolomic profiling demonstrated a marked increase in microbiota-derived metabolites, particularly along aromatic amino acid pathways. Notably, p-cresol metabolites were significantly elevated in both brain and circulation, suggesting enhanced microbial phenylalanine/tyrosine metabolism...
2026-08-21 | MTBLS14404 | MetaboLights
MetabolomicsEssential omega-3 fatty acids tune microglial phagocytosis of synaptic elements in the developing brain

Omega-3 fatty acids (n-3 polyunsaturated fatty acids; n-3 PUFAs) are essential for the functional maturation of the brain. Westernization of dietary habits in both developed and developing countries is accompanied by a progressive reduction in dietary intake of n-3 PUFAs. Low maternal intake of n...

2020-11-03 | MTBLS1952 | MetaboLights
MetabolomicsDisruption of the Brain-Spleen Axis Impairs Monocyte-Microglia Communication and Accelerates Disease Progression in a Mouse Model of Amyloidosis
Alzheimer’s disease (AD) is characterized by a prolonged asymptomatic phase before cognitive decline emerges, yet the mechanisms driving symptom onset remain unclear. Here, we hypothesized that the transition from asymptomatic to symptomatic disease is linked to dysfunction of brain–immune communica...
2026-06-01 | MTBLS14615 | MetaboLights
ProteomicsProteomics of Alzheimer's Disease mouse models - control dataset
Alzheimer’s disease (AD) is a neurodegenerative disease displaying plaques formed by the neurotoxic amyloid β-peptide (Aβ), and intracellular neurofibrillary tangles consisting of protein tau. However, how these pathologies relates to the massive neuronal death that occurs in AD brains remain elusiv...
ORGANISM(S): Mus musculus (Mouse) 
2015-07-29 | PXD001786 | Pride
Mouse brain 
TranscriptomicsSystemic inflammation modulates Fc receptor expression on microglia in chronic neurodegeneration
To investigate the inflammatory response in neurodegenerative disease during an episode of systemic inflammation using the ME7 prion model. Comparison of ME7-infected mice with mice innoculated with Normal brain homogenate (NBH). 18 weeks post-innoculation mice were administered 500ug/kg LPS or an e...
ORGANISM(S): Mus musculus 
2010-07-28 | E-GEOD-23182 | biostudies-arrayexpress
Genomics273ad39f-3094-4126-a10e-96c1321a07fb - samples
FastQ files with paired-end RNAseq data for human fetal brain homogenate from 120 samples (12-19 post-conception weeks).
EGAD00001004363 | EGA
ProteomicsHuman brain homogenate and synaptoneurosome proteomics
Investigation into PSP using proteomic techniques. Through the use of different human brain preps, the differences between those with Progressive supranuclear palsy and those without will be compared
ORGANISM(S): Homo sapiens (Human) 
2025-08-25 | PXD047282 | Pride
Brain Psp Human Dia 
ProteomicsProteomics of Alzheimer's Disease mouse models
Alzheimer’s disease (AD) is a neurodegenerative disease displaying plaques formed by the neurotoxic amyloid β-peptide (Aβ) and intracellular neurofibrillary tangles consisting of protein tau. However, how these pathologies relates to the massive neuronal death that occurs in AD brains remain elusive...
ORGANISM(S): Mus musculus (Mouse) 
2015-07-29 | PXD000968 | Pride
Mosue models Brain Lc-ms Alzheimer disease 
ProteomicsCEGS Proteomics - A multiregional proteomic survey of the postnatal human brain
Here we exploit label-free quantitative tandem mass-spectrometry proteomics to create the first in-depth quantitative proteomic survey of regions of the postnatal human brain. We adopted a dual approach to analysing these human brain samples similar to that of a recent high-quality study of the mou...
ORGANISM(S): Homo sapiens (Human) 
2018-01-09 | PXD005445 | Pride
Human brain Regions Post natal development 
UnknownSimultaneous Quantification of Brigatinib and Brigatinib-Analog in Rat Plasma and Brain Homogenate by LC-MS/MS: Application to Comparative Pharmacokinetic and Brain Distribution Studies.
Not available
S-EPMC6915135 | biostudies-literature
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