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MetabolomicsA polyamine-centric blood-based metabolite panel predictive of poor response to CAR T-cell therapy in large B cell lymphoma

Anti-CD19 chimeric antigen receptor (CAR) T-cell therapy for relapsed or refractory (r/r) large B-cell lymphoma (LBCL) results in durable response in only a subset of patients. MYC overexpression in LBCL tumors is associated with poor response to treatment. We tested whether a MYC-driven polyamin...

2022-10-31 | MTBLS5381 | MetaboLights
ProteomicsTargeting the histone methyltransferase DOT1L rewires CD8 T cells and enhances their intrinsic cytotoxic activity towards tumor cells
Insights into the epigenetic mechanisms of CD8 T cell differentiation are delivering novel opportunities for modulating fate decisions and immune responses. The histone methyltransferase DOT1L is emerging as central epigenetic regulator in immune cells. However, its cell-intrinsic role in CD8 T cell...
ORGANISM(S): Mus musculus (Mouse) 
2025-11-10 | PXD057606 | Pride
Lc-msms Epigenetics Cytotoxic cell Epigenetic targeting T cell differentiation Histone methylation Tumor immunology 
GenomicsDifferential genomic targeting of the transcription factor TAL1 in alternate hematopoietic lineages
TAL1/SCL is a master regulator of hematopoiesis whose expression promotes opposite outcomes depending on the cell type - differentiation in the erythroid lineage or oncogenesis in the T-cell lineage. Here we used a combination of ChIP-sequencing and gene expression profiling to compare the function ...
ORGANISM(S): Homo sapiens 
2010-10-30 | E-GEOD-25000 | biostudies-arrayexpress
UnknownBrand discrimination: an implicit measure of the strength of mental brand representations.
Not available
S-EPMC4372428 | biostudies-literature
UnknownCigarette brand loyalty among smokers in six European countries: Findings from the EUREST-PLUS ITC Europe Surveys.
Not available
S-EPMC6661850 | biostudies-literature
UnknownEnhancement of Vaccine-Induced T-Cell Responses by PD-L1 Blockade in Calves.
Not available
S-EPMC10051159 | biostudies-literature
UnknownReinforcement and MAO-A inhibition in heated tobacco products: flavor and brand variations.
Not available
S-EPMC11876406 | biostudies-literature
UnknownHow Preferred Brands Relate to the Self: The Effect of Brand Preference, Product Involvement, and Information Valence on Brand-Related Memory.
Not available
S-EPMC6499029 | biostudies-literature
UnknownEvolution of SARS-CoV-2-specific CD4+ T cell epitopes.
Not available
S-EPMC9887569 | biostudies-literature
UnknownGeneric and brand-name L-thyroxine are not bioequivalent for children with severe congenital hypothyroidism.
Not available
S-EPMC3565118 | biostudies-literature
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