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TranscriptomicsExpression data for human retinal pigment epithelium (RPE)/choroid - early age-related macular degeneration (AMD) and control samples
Purpose: Age-related degeneration (AMD) is a major cause of blindness in developed countries. The molecular pathogenesis of early events in AMD is poorly understood. We investigated differential gene expression in samples of human retinal pigment epithelium (RPE)/choroid from early AMD and control m...
ORGANISM(S): Homo sapiens 
2013-12-23 | E-GEOD-50195 | biostudies-arrayexpress
TranscriptomicsGene Array Analyzer (GAA): Alternative usage of gene arrays to study alternative splicing events (MoGene array)
The latest version of microarrays released by Affymetrix, the GeneChip Gene 1.0 ST Arrays (gene arrays), are designed in a similar fashion as exon arrays, which enables to identify differentially expressed exons, rather than only the expression level of whole transcripts. Here, we propose an extensi...
ORGANISM(S): Mus musculus 
2011-11-28 | E-GEOD-30429 | biostudies-arrayexpress
TranscriptomicsGene expression data from pilocytic astrocytoma tumour samples and normal cerebellum controls
Pilocytic astrocytomas (PA) are the most common brain tumor in pediatric patients and can cause significant morbidity, including chronic neurological deficiencies. They are characterized by activating alterations in the mitogen-activated protein kinase (MAPK) pathway, but little else is known about ...
ORGANISM(S): Homo sapiens 
2013-06-12 | E-GEOD-44971 | biostudies-arrayexpress
UnknownMalassezia Is Associated with Crohn's Disease and Exacerbates Colitis in Mouse Models.
Not available
S-EPMC6417942 | biostudies-literature
TranscriptomicsSystems-level analysis of N-starvation induced modifications of carbon metabolism in a Chlamydomonas starchless mutant
To understand the molecular basis underlying increased triacylglycerol accumulation in starchless Chlamydomonas mutants, we undertook comparative time course transcriptomics of sta6 (CC-4348), a cw strain purported to represent the parental STA6 strain (CC-4349), and 3 independent STA6 strains (STA6...
ORGANISM(S): Chlamydomonas reinhardtii 
2013-10-24 | E-GEOD-51602 | biostudies-arrayexpress
TranscriptomicsNeurofibromin (Nf1) is required for skeletal muscle development
Neurofibromatosis type 1 (NF1) is a multi-system disease caused by mutations in the NF1 gene encoding a Ras-GAP protein, neurofibromin, which negatively regulates Ras signalling. Besides neuroectodermal malformations and tumours, the skeletal system is often affected (e.g. scoliosis and long bone dy...
ORGANISM(S): Mus musculus 
2011-05-18 | E-GEOD-29343 | biostudies-arrayexpress
GenomicsETEC H10407 ChIP-Seq
To generate and compile data from ChIP-Seq libraries. Looking at CRP, H-NS, and sigma70 binding genome wide under M9 minimal growth conditions in duplicate.
ORGANISM(S): Escherichia coli ETEC H10407 
2014-10-16 | E-MTAB-2917 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse mesangial cell line MES-13 to examine the global effects of high glucose (HG) and glucosamine (GlcN) on the transcriptome.
The renal mesangial cells play an important role in the development of diabetic glomerulosclerosis and renal failure. We have previously demonstrated some of the effects of high glucose are mediated via the hexosamine biosynthesis pathway (HBP) in which fructose-6-phosphate is converted to glucosami...
ORGANISM(S): Mus musculus 
2007-12-01 | E-GEOD-2557 | biostudies-arrayexpress
TranscriptomicsTranscription profiling time series of Candida albicans treated with different doses of acetic acid
Wild type Candida albicans (CAI8 containing CIp10) cultures were grown in triplicate at 1 x 107 cells ml-1 in 50 ml SC-pH3.0 broth. Cultures were then treated with 0, 20, 120 or 300
mM acetic acid. Cells were harvested after zero, 10, 30, 60, 120, 210 and 300 min treatment. RNA isolated from tri...
ORGANISM(S): Candida albicans 
2008-07-31 | E-MEXP-1645 | biostudies-arrayexpress
TranscriptomicsTranscriptome and translational signaling following endurance exercise in trained skeletal muscle: impact of dietary protein
Impact of protein ingestion following 1 h intense cycling on the induced transcriptome and signaling in biopsy samples from endurance-trained men, relative to isocaloric control Single blind, randomized, crossover design comprising two experimental blocks. During the blocks, exercise and diet were c...
ORGANISM(S): Homo sapiens 
2011-11-21 | E-GEOD-27285 | biostudies-arrayexpress
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