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MetabolomicsMulti-omics characterization of acquired Olaparib resistance in BRCA1 and BRCA2 mutant breast cancer cell lines
Poly (ADP-ribose) polymerase inhibitors (PARPi) are widely used as targeted therapies against breast cancers with BRCA mutations. However, the development of resistance to PARPi poses a significant challenge for long-term efficacy of these therapies, warranting further understanding of mechanisms of...
2026-05-11 | MTBLS12109 | MetaboLights
MetabolomicsMetabolic study of BRCA1 knockout cells and WT cells in homo sapiens

BRCA1 mutations are a hallmark of hereditary ovarian cancer, strongly linked to deficiencies in homologous recombination (HR) DNA repair and impaired DNA replication fork protection. However, its roles in cancer progression beyond maintaining genomic integrity remain poorly understood. Through me...

2026-05-15 | MTBLS12245 | MetaboLights
TranscriptomicsA gene expression profile of BRCAness that is associated with outcome in ovarian cancer
A gene expression profile of BRCAness was defined in publicly available expression data of 61 patients with epithelial ovarian cancer (34 patients with BRCA-1 or BRCA-2 mutations and 27 patients with sporadic disease). This dataset is publicly available at http://jnci.oxfordjournals.org/cgi/content/...
ORGANISM(S): Homo sapiens 
2010-07-11 | E-GEOD-19829 | biostudies-arrayexpress
ProteomicsIdentification of BRCA1-associated protein 1 (BAP1)-associated proteins
BRCA1-associated protein 1 (BAP1) is a multidomain deubiquitinase (DUB) with a ubiquitin carboxyl-terminal hydrolase (UCH) domain at its N-terminus. BAP1 mainly localizes in the nucleus and primarily functions as a transcriptional regulator in diverse cellular pathways, including cell proliferation...
ORGANISM(S): Homo sapiens (Human) 
2022-04-14 | PXD030044 | Pride
Human Bap1 Tumor suppressor Brca-1 associated protein 1 Deubiquitinase Dub 
ProteomicsTargeting immunosuppressive macrophages overcomes PARP-inhibitor resistance in BRCA1-associated triple-negative breast cancer
Despite objective responses to PARP inhibition and improvements in progression-free survival compared to standard chemotherapy in patients with BRCA-associated triple-negative breast cancer (TNBC), benefits are transitory. Using high dimensional single-cell profiling of human TNBC, here we demonstra...
ORGANISM(S): Homo sapiens (Human) 
2021-03-25 | PXD015804 | Pride
Tam (tumor associated macrophage) Tmt Parp Lumos 
UnknownBRCA-associated protein 1 (BAP1) and miR-31 combination predicts outcomes in epithelioid malignant pleural mesothelioma.
Not available
S-EPMC8575852 | biostudies-literature
GenomicsInterpheron-γ signaling is associated with BRCA-1 loss-of-function mutations in high grade serous ovarian cancer [ChIP-seq]
Interpheron-γ signaling is associated with BRCA-1 loss-of-function mutations in high grade serous ovarian cancer [ChIP-seq]
PRJNA542709 | ENA
GenomicsInterpheron-γ signaling is associated with BRCA-1 loss-of-function mutations in high grade serous ovarian cancer [RNA-seq]
Interpheron-γ signaling is associated with BRCA-1 loss-of-function mutations in high grade serous ovarian cancer [RNA-seq]
PRJNA542650 | ENA
UnknownLack of association between a functional variant of the BRCA-1 related associated protein (BRAP) gene and ischemic stroke.
Not available
S-EPMC3564782 | biostudies-literature
TranscriptomicsExpression profiling of peripheral blood gene expression of women with hereditary breast cancer and controls (set 1)
We obtained peripheral blood samples for women from Utah (USA) and Ontario (Canada) who had a family history of breast cancer (or did not), who carried a BRCA1/2 mutation (or did not), and who had developed breast cancer (or had not). We classified the women into two groups: [1] those who had a fami...
ORGANISM(S): Homo sapiens 
2015-10-21 | E-GEOD-47860 | biostudies-arrayexpress
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