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ProteomicsPhysiological basis of contraceptive function of a GSK3α-selective inhibitor, manifested during epididymal sperm maturation
Glycogen synthase kinase 3 alpha (GSK3α) has emerged as a prospective target to develop male contraceptives. The GSK3α paralog is highly conserved and present in the sperm of placental mammals. Global or testis-specific loss of GSK3α, but not GSK3β, results in male infertility. A preliminary study ...
ORGANISM(S): Mus musculus (Mouse) 
2026-07-29 | PXD079474 | Pride
Brd0705 Male contraceptive Glycogen synthase kinase 3 alpha Sperm maturation Spermatogenesis Phosphoproteomics 
ProteomicsAsparaginase and GSK3A inhibitor treatment of CCRF-CEM cells
Resistance to asparaginase, an antileukemic enzyme that depletes asparagine, is a common clinical problem. Using a genome-wide CRISPR/Cas9 screen, we found a synthetic lethal interaction between Wnt pathway activation and asparaginase in acute leukemias resistant to this enzyme. Wnt pathway activa...
ORGANISM(S): Homo sapiens (Human) 
2019-03-29 | PXD013061 | Pride
Gsk3 Leukemia Asparaginase 
GenomicsSelective GSK3α Inhibition Promotes Self-Renewal Across Different Stem Cell States [CUT&Tag]
Mouse embryonic stem cells (ESCs) and epiblast stem cells (EpiSCs) represent the naïve and primed pluripotent states, respectively, each requiring distinct culture conditions. In this study, we show that BRD0705, a selective GSK3α inhibitor, significantly enhances the self-renewal of both ESCs and E...
ORGANISM(S): Mus musculus 
2025-06-16 | GSE295265 | GEO
TranscriptomicsSelective GSK3α Inhibition Promotes Self-Renewal Across Different Stem Cell States [scRNA-seq]
Mouse embryonic stem cells (ESCs) and epiblast stem cells (EpiSCs) represent the naïve and primed pluripotent states, respectively, each requiring distinct culture conditions. In this study, we show that BRD0705, a selective GSK3α inhibitor, significantly enhances the self-renewal of both ESCs and E...
ORGANISM(S): Mus musculus 
2025-06-16 | GSE295264 | GEO
TranscriptomicsGSK3α functions as a stemness checkpoint across multiple stem cell states
Mouse embryonic stem cells (ESCs) and epiblast stem cells (EpiSCs) represent the naïve and primed pluripotent states, respectively, each requiring distinct culture conditions. In this study, we show that BRD0705, a selective GSK3α inhibitor, significantly enhances the self-renewal of both ESCs and E...
ORGANISM(S): Mus musculus 
2026-03-16 | GSE304689 | GEO
TranscriptomicsSelective GSK3α Inhibition Promotes Self-Renewal Across Different Stem Cell States [RNA-seq]
Mouse embryonic stem cells (ESCs) and epiblast stem cells (EpiSCs) represent the naïve and primed pluripotent states, respectively, each requiring distinct culture conditions. In this study, we show that BRD0705, a selective GSK3α inhibitor, significantly enhances the self-renewal of both ESCs and E...
ORGANISM(S): Mus musculus 
2025-06-16 | GSE295263 | GEO
UnknownExploiting an Asp-Glu "switch" in glycogen synthase kinase 3 to design paralog-selective inhibitors for use in acute myeloid leukemia.
Not available
S-EPMC6553635 | biostudies-literature
UnknownA non-hormonal reversible contraceptive targeting GSK3α, a protein kinase, essential for epididymal sperm maturation.
Not available
S-EPMC12569727 | biostudies-literature
TranscriptomicsGenome-wide transcriptional profile for the GSK3β selective inhibitor BRD3731
Exploiting an Asp-Glu “switch” in glycogen synthase kinase 3 to design paralog selective inhibitors for use in acute myeloid leukemia: Genome-wide transcriptional profile for the GSK3β selective inhibitor BRD3731. Glycogen synthase kinase 3 (GSK3), a key regulatory kinase in the WNT pathway, remains...
ORGANISM(S): Homo sapiens 
2019-06-16 | GSE109986 | GEO
TranscriptomicsGenome-wide transcriptional profiles for the GSK3α selective inhibitor BRD0507 and for the GSK3α/β dual inhibitor BRD0320
Exploiting an Asp-Glu “switch” in glycogen synthase kinase 3 to design paralog selective inhibitors for use in acute myeloid leukemia: Genome-wide transcriptional profiles for the GSK3α selective inhibitor BRD0507 and for the GSK3α/β dual inhibitor BRD0320 Glycogen synthase kinase 3 (GSK3), a key re...
ORGANISM(S): Homo sapiens 
2019-06-16 | GSE109985 | GEO
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