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ProteomicsIdentification of naturally short gamma-secretase substrates
The intramembrane protease gamma-secretase has broad physiological functions, but also contributes to Notch-dependent tumors and Alzheimer’s disease. To identify naturally short substrates and non-substrates of gamma-secretase, we used four human cell lines of different tissue origins, breast cancer...
ORGANISM(S): Homo sapiens (Human) 
2024-05-24 | PXD045701 | Pride
Dapt Human Gamma-secretase Intramembrane protease 
ProteomicsProteomic and lipidomic profiling of demyelinating lesions identifies fatty acids as modulators in inflammation resolution
After demyelinating injury of the central nervous system, resolution of the mounting acute innate inflammation is crucial for the initiation of a regenerative response. To identify factors in lesion recovery after demyelination injury, we used a toxin-induced model, in which a single dose of lysolec...
ORGANISM(S): Mus musculus (Mouse) 
2021-09-30 | PXD024891 | Pride
Demyelination Oligodendrocytes Myelin Microglia 
UnknownADAM10 and ADAM17 promote SARS-CoV-2 cell entry and spike protein-mediated lung cell fusion
Not available
S-SCDT-EMBOR-2021-54305V1 | biostudies-other
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