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MetabolomicsGeographic variation of mutagenic exposures in kidney cancer genomes

International differences in the incidence of many cancer types indicate the existence of carcinogen exposures that have not been identified by conventional epidemiology yet potentially make a substantial contribution to cancer burden1. This pertains to clear cell renal cell carcinoma (ccRCC), fo...

2024-03-26 | MTBLS9394 | MetaboLights
ProteomicsProtein aggregation mediates protein complex stoichiometry in aneuploid cells, part 1
Aneuploidy, a condition characterized by chromosome gains and losses, causes reduced fitness and numerous cellular stresses, including increased protein aggregation. Here, we identify protein complex stoichiometry imbalances as a major cause of protein aggregation in aneuploid cells. Subunits of pro...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2020-05-26 | PXD011874 | Pride
Yeast Aggregates Proteostasis Aneuploidy 
ProteomicsProtein aggregation mediates protein complex stoichiometry in aneuploid cells, part 6
Aneuploidy, a condition characterized by chromosome gains and losses, causes reduced fitness and numerous cellular stresses, including increased protein aggregation. Here, we identify protein complex stoichiometry imbalances as a major cause of protein aggregation in aneuploid cells. Subunits of pro...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2020-05-26 | PXD011915 | Pride
Yeast Aggregates Proteostasis Aneuploidy 
ProteomicsProtein aggregation mediates protein complex stoichiometry in aneuploid cells, part 7
Aneuploidy, a condition characterized by chromosome gains and losses, causes reduced fitness and numerous cellular stresses, including increased protein aggregation. Here, we identify protein complex stoichiometry imbalances as a major cause of protein aggregation in aneuploid cells. Subunits of pro...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2020-05-26 | PXD011916 | Pride
Yeast Proteostasis Aneuploidy Aggregate 
ProteomicsProtein aggregation mediates protein complex stoichiometry in aneuploid cells, part 4
Aneuploidy, a condition characterized by chromosome gains and losses, causes reduced fitness and numerous cellular stresses, including increased protein aggregation. Here, we identify protein complex stoichiometry imbalances as a major cause of protein aggregation in aneuploid cells. Subunits of pro...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2020-05-26 | PXD011877 | Pride
Yeast Proteostasis Aneuploidy Aggregate 
ProteomicsProtein aggregation mediates protein complex stoichiometry in aneuploid cells, part 5
Aneuploidy, a condition characterized by chromosome gains and losses, causes reduced fitness and numerous cellular stresses, including increased protein aggregation. Here, we identify protein complex stoichiometry imbalances as a major cause of protein aggregation in aneuploid cells. Subunits of pro...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2020-05-26 | PXD011878 | Pride
Yeast Proteostasis Aneuploidy Aggregate 
ProteomicsProtein aggregation mediates protein complex stoichiometry in aneuploid cells, part 2
Aneuploidy, a condition characterized by chromosome gains and losses, causes reduced fitness and numerous cellular stresses, including increased protein aggregation. Here, we identify protein complex stoichiometry imbalances as a major cause of protein aggregation in aneuploid cells. Subunits of pro...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2020-05-26 | PXD011875 | Pride
Yeast Aggregates Proteostasis Aneuploidy 
ProteomicsProtein aggregation mediates protein complex stoichiometry in aneuploid cells, part 3
Aneuploidy, a condition characterized by chromosome gains and losses, causes reduced fitness and numerous cellular stresses, including increased protein aggregation. Here, we identify protein complex stoichiometry imbalances as a major cause of protein aggregation in aneuploid cells. Subunits of pro...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2020-05-26 | PXD011876 | Pride
Yeast Proteostasis Aneuploidy Aggregate 
GenomicsThe Ovarian Cancer Association Consortium Data Access Committee
Data Access Committee EGAC00001000616
EGAC00001000616 | EGA
GenomicsThe Ovarian Cancer Association Consortium OncoArray genome-wide association study
A custom Illumina genotyping array, the OncoArray. The array includes a genome-wide backbone, comprising 230,000 SNPs tagging most common genetic variants, together with dense mapping of known susceptibility regions, rare variants from sequencing experiments, pharmacogenetic markers, and cancer-rela...
EGAS00001002305 | EGA
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