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TranscriptomicsNatural Genetic Variation Influences Protein Abundances in C. elegans Developmental Signalling Pathways
Complex traits, including common disease-related traits, are affected by many different genes that function in multiple pathways and networks. The apoptosis, MAPK, Notch and Wnt signalling pathways play important roles in development and disease progression. At the moment we have a poor understandin...
ORGANISM(S): Caenorhabditis elegans 
2016-02-16 | E-GEOD-77905 | biostudies-arrayexpress
TranscriptomicsDeep sequencing of endogenous mRNA from Caenorhabditis elegans in the presence and absence of 1-methylnicotinamide (MNA) and nicotinic acid (NA)
Sirtuins, a family of histone deacetylases, have a fiercely debated role in regulating lifespan of different species. Contrasting recent observations, we here find that overexpression of sir-2.1, the orthologue of mammalian SirT1, does extend C. elegans lifespan. Sirtuins are known to convert NAD+ i...
ORGANISM(S): Caenorhabditis elegans 
2013-08-09 | E-GEOD-49662 | biostudies-arrayexpress
TranscriptomicsWhole-exome sequencing (WES) to assess genomic concordance between an adenoma/adenocarcinoma colonoid culture 14-881 and the source patient tissue
A patient-derived epithelium-only colon rectal organoid, also referred to as a colonoid, was generated from an adenoma (associated with a resection surgery of an invasive moderately differentiated colorectal adenocarcinoma) as part of the development of an on-going organoid biobank at the Michigan M...
ORGANISM(S): Homo sapiens 
2020-12-22 | E-MTAB-9936 | biostudies-arrayexpress
UnknownLithium Treatment in the Prevention of Repeat Suicide-Related Outcomes in Veterans With Major Depression or Bipolar Disorder: A Randomized Clinical Trial.
Not available
S-EPMC8600458 | biostudies-literature
UnknownThe effect of sample size on polygenic hazard models for prostate cancer.
Not available
S-EPMC7608255 | biostudies-literature
UnknownA Genetic Risk Score to Personalize Prostate Cancer Screening, Applied to Population Data.
Not available
S-EPMC7483627 | biostudies-literature
UnknownAssociation of Chromosome 9p21 With Subsequent Coronary Heart Disease Events.
Not available
S-EPMC6625876 | biostudies-literature
UnknownPALB2, CHEK2 and ATM rare variants and cancer risk: data from COGS.
Not available
S-EPMC5200636 | biostudies-literature
UnknownGermline variation at 8q24 and prostate cancer risk in men of European ancestry.
Not available
S-EPMC6218483 | biostudies-literature
UnknownA genome-wide gene-environment interaction study of breast cancer risk for women of European ancestry.
Not available
S-EPMC10411002 | biostudies-literature
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