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TranscriptomicsADAR1-mediated A-to-I RNA editing is essential for erythropoiesis [RNA-seq]
Purpose: RNA editing by ADAR1 is essential for hematopoietic development. The goals of this study were firstly, to identify ADAR1-specific RNA-editing sites by indentifying A-to-I (G) RNA editing sites in wild type mice that were not edited or reduced in editing frequency in ADAR1 deficient murine e...
ORGANISM(S): Mus musculus 
2016-07-24 | E-GEOD-71042 | biostudies-arrayexpress
UnknownMulti-gene incongruence consistent with hybridisation in Cladocopium (Symbiodiniaceae), an ecologically important genus of coral reef symbionts.
Not available
S-EPMC6598746 | biostudies-literature
GenomicsThe p23 molecular chaperone and GCN5 acetylase jointly modulate protein-DNA dynamics and open chromatin status.
Dense mapping of individual DNase I cleavages from intact nuclei isolated from wild type, sba1M-NM-^T and gcn5M-NM-^T yeast using high-throughput sequencing. Open chromatin status of wild type, sba1-/- and gcn5-/- yeast strains were generated by Dnase-seq.
ORGANISM(S): Saccharomyces cerevisiae 
2012-08-23 | E-GEOD-40255 | biostudies-arrayexpress
ProteomicsEZH2 loss during metabolic stress drives restoration of MHC Class I machinery in melanoma
Unleashing the immune anti-tumor response through immune checkpoint blockade (ICB) has been successful in treating many solid-tumor malignancies, including metastatic melanoma. When successful, the ICB response can be potent; however, half of patients fail to respond. ICB responsiveness is impacted ...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2024-08-13 | MSV000095589 | MassIVE
ProteomicsPlant-derived virus-like particle vaccines drive cross-presentation of influenza A hemagglutinin peptides by human monocyte-derived macrophages
A growing body of evidence supports the importance of T cell responses to protect against severe influenza, promote viral clearance and ensure long-term immunity. Plant-derived virus-like particle (VLP) vaccines bearing influenza hemagglutinin (HA) have been shown to elicit strong humoral and CD4+ T...
ORGANISM(S): Homo sapiens (Human) 
2019-05-28 | PXD010519 | Pride
Influenza Cell-mediated immunity Cross-presentation Major histocompatibility complex class i Human monocyte-derived macrophage High-resolution mass spectrometry Plant-derived vaccine Virus-like particle 
TranscriptomicsCathepsin K Contributes to Cavitation and Collagen Turnover in Pulmonary Tuberculosis
Cavitation in tuberculosis (TB) enables highly efficient person-to-person aerosol transmission. Currently, a number of hypotheses exist regarding the mechanisms underlying this process. To explore this process, we undertook an unbiased next-generation transcriptional analysis of samples from cavity ...
ORGANISM(S): Oryctolagus cuniculus 
2015-11-03 | E-GEOD-68206 | biostudies-arrayexpress
GenomicsGenomic Sequencing of Medulloblastoma

Medulloblastomas are the most common malignant brain tumors in children. Identifying and understanding the genetic events that drive these tumors is critical for the development of more effective diagnostic, prognostic and therapeutic strategies. Recently, our group and others described distinct ...

phs000504.v1.p1 | EGA
UnknownHuman genomic DNA is widely interspersed with i-motif structures
Not available
S-SCDT-10_1038-S44318-024-00210-5 | biostudies-other
GenomicsNext Generation Mendelian Genetics: Atypical Werner Syndrome

Werner syndrome (WS) is an adult-onset progeroid syndrome characterized by accelerated aging. The International Registry of Werner Syndrome in the Department of Pathology, University of Washington, collects WS cases from all over the world. Classical WS is caused by WRN mutations. Those who do no...

phs000434.v1.p1 | EGA
TranscriptomicsmiRNA profiles of brain glioma stem cells and normal neural stem cells
A human microarray comprising 1658 human genome probes was used to evaluate the specific expression of miRNA between brian glioma stem cells (GSC) and normal neural stem cells(NSC). 2 total RNA samples are analyzed, brian glioma stem cells (GSC) and normal neural stem cells(NSC). cell type: brain g...
ORGANISM(S): Homo sapiens 
2014-07-30 | E-GEOD-41032 | biostudies-arrayexpress
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