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MetabolomicsShotgun lipidomics of HeLa whole-cell lysates and lysosomes following LLOMe treatment

Perturbations in lysosome integrity are tightly linked to neurological disorders and ageing, but the underlying pathogenic mechanisms are incompletely understood. Using an unbiased proteomic approach, we here identified the bridge-like lipid transport protein VPS13C/PARK23 as a key component of a...

2026-07-03 | MTBLS14737 | MetaboLights
ProteomicsBridge-like lipid transfer protein 3A (BLTP3A) is associated with membranes of the late endocytic pathway and is an effector of CASM
Recent studies have identified a family of rod-shaped proteins which includes VPS13 and ATG2 and are thought to mediate unidirectional lipid transport at intracellular membrane contacts by a bridge-like mechanism. Here, we show that one such protein, BLTP3A/UHRF1BP1, associates with VAMP7-positive v...
ORGANISM(S): Homo sapiens (Human) 
2025-08-28 | PXD056338 | Pride
Lysosome Lysosomal membrane damage Bltp Bltp3b Bltp3a Casm Rab7 Bridge-like lipid transfer protein 
UnknownBridge-like lipid transfer protein family member 2 suppresses ciliogenesis.
Not available
S-EPMC11151097 | biostudies-literature
ProteomicsIdentification of proteins in proximity to VAP and VPS13L1 in P. falciparum blood stages
P. falciparum blood stage parasites maintain an intricate system of membranes, requiring precise mechanisms of lipid synthesis and trafficking. Lipid transfer proteins (LTPs) at interorganelle membrane contact sites (MCSs) have emerged as key for ensuring proper lipid distribution in cells but so fa...
ORGANISM(S): Plasmodium falciparum (isolate 3D7) 
2025-07-28 | PXD066159 | Pride
Malaria Membrane contact sites Erythrocytic stages Lipid transfer proteins Bioid 
UnknownInsights into the regulation of VPS13 family bridge-like lipid transfer proteins from the structure of VPS13C.
Not available
S-EPMC12642616 | biostudies-literature
UnknownThe bridge-like lipid transfer protein (BLTP) gene group: introducing new nomenclature based on structural homology indicating shared function.
Not available
S-EPMC9719229 | biostudies-literature
UnknownIn silico modeling human VPS13 proteins associated with donor and target membranes suggests lipid transfer mechanisms.
Not available
S-EPMC10953354 | biostudies-literature
UnknownHoi1 targets the yeast BLTP2 protein to ER-PM contact sites to regulate lipid homeostasis.
Not available
S-EPMC11844476 | biostudies-literature
UnknownA role for Vps13-mediated lipid transfer at the ER-endosome contact site in ESCRT-mediated sorting.
Not available
S-EPMC10847051 | biostudies-literature
ProteomicsVPS13C/PARK23 initiates lipid transfer and membrane remodeling for efficient lysosomal repair
Perturbations in lysosome integrity are frequently linked to neurological disorders and ageing, but the underlying pathogenic mechanisms are incompletely understood. Using an unbiased proteomic approach, we here identified the bridge-like lipid transport protein VPS13C/PARK23 as a key component of a...
ORGANISM(S): Homo sapiens (Human) 
2026-07-13 | PXD069825 | Pride
Human Lysosomal repair Vps13c Lysosome purification 
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