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ProteomicsMitochondrial IntegrityMitochondrial Integrity Modulates mTOR Signaling and Podocyte Function Modulates mTOR Signaling and Podocyte Function
Mitochondrial dysfunction has emerged as a key contributor to the pathogenesis of steroid-resistant nephrotic syndrome (SRNS) and genetic focal-segmental glomerulosclerosis (FSGS). This study explores the role of mitochondrial integrity in podocyte biology, focusing on the impact of OMA1, a critical...
ORGANISM(S): Mus musculus (Mouse) 
2025-11-26 | PXD071171 | Pride
Mitochondria Glycolysis 
ProteomicsPar3A and Par3B interactome IMCDs
We assessed the functional role of the cell polarity proteins Par3A and B in inner medullary collecting duct cells (IMCD). Here, we did an interactome analysis from IMCDs after transiently transfecting Par3A or Par3B with a flag tag.
ORGANISM(S): Mus musculus (Mouse) 
2022-07-07 | PXD018637 | Pride
Par3b Imcd cells Par3a 
ProteomicsDrosophila nephrocytes Bazooka knockdown vs control
We assessed the functional role of the cell polarity protein Bazooka on nephrocyte function. Here, we did a proteomics anaylsis of isolated garland nephrocytes from 3rd install larvae. Analysis of the data identified several differentially regulated proteins.
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2022-07-07 | PXD018635 | Pride
Nephrocyte Bazooka Drosophila 
ProteomicsDrosophila nephrocytes Par3A and B rescue
We assessed the functional role of the cell polarity proteins Par3A and B in Bazooka Knockdown nephrocytes. Here, we did a proteomics anaylsis of isolated garland nephrocytes from 3rd instar larvae. Analysis of the data identified differentially regulated proteins.
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2022-07-07 | PXD018636 | Pride
Nephrocyte Bazooka Drosophila Par3 
OtherComparative phosphoproteomic analysis of mammalian glomeruli reveals conserved podocin C-terminal phosphorylation as a determinant of slit diaphragm complex architecture.
Data from ProteomeXchange, PXD ID: PXD001005. Experiment: 130104MaRiS_TpD, file: 0089-130104MaRiS04TpD.mzml. Published as part of Proteomics. 2014 Nov 25 . From the Abstract: {{i}} Glomerular biology is dependent on tightly controlled signal transduction networks that control phosphorylation of sig...
ORGANISM(S): Rat 
GPM32320007078 | GPMDB
Resource Reanalysis 
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