Sort   by:  
 Page size 
MetabolomicsAngiopoietin-like 4 governs diurnal lipoprotein lipase activity in brown adipose tissue.

OBJECTIVE: Brown adipose tissue (BAT) burns fatty acids (FAs) to produce heat, and shows diurnal oscillation in glucose and triglyceride (TG)-derived FA-uptake, peaking around wakening. Here we aimed to gain insight in the diurnal regulation of metabolic BAT activity.

2023-11-15 | MTBLS4082 | MetaboLights
TranscriptomicsTranscription profiling of rat liver samples from animals treated with D-penicillamine and controls
Idiosyncratic drug reactions (IDRs) cause significant morbidity and mortality. In an animal model of IDRs, 50-80% of Brown Norway rats exposed to D-penicillamine develop an autoimmune syndrome after several weeks of treatment. The symptoms of the IDR are similar to that observed in humans who take D...
ORGANISM(S): Rattus norvegicus 
2007-10-10 | E-GEOD-2825 | biostudies-arrayexpress
TranscriptomicsBiological Aging and Circadian Mechanisms in Murine Brown Adipose Tissue, Inguinal White Adipose Tissue, and Liver (Jan 2010 dataset)
The circadian profile of the transcriptomes in murine tissues was compared between groups of young and old male mice. The oscillatory phase and absolute expression levels were evaluated as a function of biological age. Distinct differences in multiple pathways were apparent based on biological and c...
ORGANISM(S): Mus musculus 
2012-03-15 | E-GEOD-25324 | biostudies-arrayexpress
TranscriptomicsBiological Aging and Circadian Mechanisms in Murine Brown Adipose Tissue, Inguinal White Adipose Tissue, and Liver
This SuperSeries is composed of the following subset Series: GSE25323: Biological Aging and Circadian Mechanisms in Murine Brown Adipose Tissue, Inguinal White Adipose Tissue, and Liver (Nov 2009 dataset) GSE25324: Biological Aging and Circadian Mechanisms in Murine Brown Adipose Tissue, Inguinal Wh...
ORGANISM(S): Mus musculus 
2012-03-15 | E-GEOD-25325 | biostudies-arrayexpress
TranscriptomicsBiological Aging and Circadian Mechanisms in Murine Brown Adipose Tissue, Inguinal White Adipose Tissue, and Liver (Nov 2009 dataset)
The circadian profile of the transcriptomes in murine tissues was compared between groups of young and old male mice. The oscillatory phase and absolute expression levels were evaluated as a function of biological age. Distinct differences in multiple pathways were apparent based on biological and c...
ORGANISM(S): Mus musculus 
2012-03-15 | E-GEOD-25323 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of primary rat hippocampal culture cells overexpressing an activated form of calcineurin
Micorarray analysis was performed on RNA samples from hippocampal cultures infected with either Ad-aCaN or Ad-LacZ or uninfected. Each sample was applied to its own GeneChip (Rat RG-U34A; n=7-9 chips/group). Chips were then processed and scanned using Agilent Affymetrix GeneArray Scanner. MAS5 was u...
ORGANISM(S): Rattus norvegicus 
2007-09-15 | E-GEOD-1978 | biostudies-arrayexpress
TranscriptomicsEffect of hepatocyte FGF21 on brown adipose tissue gene expression in mice
FGF21 is an hepatokine, a liver-derived hormone, that is highly induced and secreted in response to fasting. We investigated the role of hepatic FGF21 on gene expression profile in the brown adipose tissue. The effect of 20h fasting on brown adipose tissue gene expression was investigated in male wi...
ORGANISM(S): Mus musculus 
2026-10-17 | E-MTAB-15855 | biostudies-arrayexpress
MetabolomicsEffects of a Compound from the Group of Substituted Thiadiazines with Hypothermia Inducing Properties on Brain Metabolism in Rats, a Study In Vivo and In Vitro
The aim of the present study was to examine how administration of a compound of 1,3,4-thiadiazine class 2-morpholino-5-phenyl-6H-1,3,4-thiadiazine hydrobromide (L-17) with hypothermia inducing properties affects the brain metabolism. The mechanism by which L-17 induces hypothermia is unknown; it may...
2018-07-27 | MTBLS482 | MetaboLights
TranscriptomicsTranscription profiling of human neurons with and without neurofibriallary tangles from Alzheimer's patients
Alzheimer's Disease (AD) is a devastating neurodegenerative disorder affecting approximately 4 million people in the U.S. alone. AD is characterized by the presence of senile plaques and neurofibrillary tangles in cortical regions of the brain. These pathological markers are thought to be responsi...
ORGANISM(S): Homo sapiens 
2009-09-05 | E-GEOD-4757 | biostudies-arrayexpress
ProteomicsFasting upregulates the monocarboxylate transporter Mct1 at the rat blood-brain barrier through Ppar d activation
Fasting is increasingly recognized as a potential therapeutic intervention in the field of neurology and psychiatry. However, its impact upon the blood-brain barrier (BBB), which strictly regulates the cerebral uptake of a wide range of endogenous compounds and drugs, is unknown. In this study we us...
ORGANISM(S): Cellular Organisms 
2024-08-15 | PXD044587 | JPOST Repository
Sort   by:  
 Page size