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ProteomicsSWATH proteomics reveals that reductants selectively disrupt collagen homeostasis in human dermal fibroblasts and modify growth factor-independent signalling through the MAPK/Akt pathway
We have used an unbiased, label-free SWATH proteomic approach to quantitate the response of skin fibroblast cells to the reductant DTT in the presence or absence of the growth factor PDGF. Of the 4487 proteins that were identified, only 47 proteins showed a statistically significant change of 2-fold...
ORGANISM(S): Homo sapiens (Human) 
2019-03-25 | PXD010747 | Pride
Skin fibroblasts Redox signalling Mapk Swath Collagen Pdgf 
MetabolomicsPeripheral modulation of antidepressant targets MAO-B and GABAAR by harmol induces mitohormesis and delays aging in preclinical models
Reversible and sub-lethal stresses to the mitochondria elicit a program of compensatory responses that ultimately improve mitochondrial function, a conserved anti-aging mechanism termed mitohormesis. Here, we show that harmol, a member of the beta-carbolines family with anti-depressant properties, i...
2023-05-26 | MTBLS7533 | MetaboLights
UnknownPeer-assisted HIV partner notification services to strengthen index partner testing for newly diagnosed men who have sex with men in coastal Kenya.
Not available
S-EPMC12503256 | biostudies-literature
ProteomicsHeat stress triggers protein secretion into the extracellular matrix of sorghum cell suspension cultures
Plants reprogram gene expression as an adaptive response to survive high temperatures. While the identity and functions of intracellular heat stress-responsive proteins have been extensively studied, the heat response of proteins secreted to the extracellular matrix is unknown. Here, we used Sorghum...
ORGANISM(S): Sorghum bicolor 
2020-10-29 | PXD021536 | Pride
Sorghum Itraq Heat stress 
ProteomicsSUMO conjugation to the pattern recognition receptor FLS2 triggers intracellular signalling in plant innate immunity
Arabidopsis lines expressing 35S::Strep-SUMO1H89R in Col-0 background were generated since the H89R SUMO1 variant simplifies MS/MS detection of SUMO conjugated lysines after trypsinization (Miller et al., 2010). Transgenic seedlings were treated with water or 250nM flg22 for 30 minutes and total pro...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2019-11-12 | PXD011552 | Pride
Arabidopsis thaliana Tripletof 6600 Fls2 Seedlings Sumo Lc-ms/ms 
UnknownEffect of low-volume exercise on hepatic steatosis in adults with obesity plus normal glucose, prediabetes or type 2 diabetes: a randomised controlled trial.
Not available
S-EPMC11448222 | biostudies-literature
UnknownAssociation scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants.
Not available
S-EPMC2680141 | biostudies-literature
UnknownProtocol for precision editing of endogenous Chlamydomonas reinhardtii genes with CRISPR-Cas.
Not available
S-EPMC10762519 | biostudies-literature
TranscriptomicsTranscription profiling of rat livers treated with pharmaceutical development compounds
We used microarrays to analyze gene expression changes in liver after treatment of rats with two compounds from drug development (R1, R2) to identify potential effects related to hepatotoxicity. Experiment Overall Design: Compound R1 or R2, or vehicle control, was given for either 24h or 2 weeks (33...
ORGANISM(S): Rattus norvegicus 
2009-08-09 | E-GEOD-17388 | biostudies-arrayexpress
ProteomicsFritz_STK11KO_MIB_2020_TripleTOF5600_complete
The files are associated with a manuscript submitted for publication by Jamie Lee Fritz et al. The main goal of this paper was to identify potential substrates for LKB1, a master kinase that is required for epithelial ovarian cancer spheroid viability and metastasis.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-05-15 | MSV000085415 | MassIVE
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