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GenomicsNotch1-driven epigenetic changes in a mouse model of T cell Acute Lymphoblastic Leukemia (T-ALL)
T-cell acute lymphoblastic leukemia (T-ALL) is an immature hematopoietic malignancy driven mainly by oncogenic activation of NOTCH1 signaling. In this study we used a mouse model of T-ALL through the overexpression of the intarcellular transcriptionally active part of Notch1 (N1-IC). This model fait...
ORGANISM(S): Mus musculus 
2012-01-10 | E-GEOD-34954 | biostudies-arrayexpress
TranscriptomicsMiRNA expression in adipose tissue and liver from a spontaneous rat model of Type 2 diabetes
MicroRNAs (miRNAs) are non-coding RNA molecules involved in post-transcriptional control of gene expression of a wide number of genes, including those involved in glucose homeostasis. Type 2 diabetes (T2D) is characterized by hyperglycaemia and defects in insulin secretion and action at target tissu...
ORGANISM(S): Rattus norvegicus 
2010-05-16 | E-GEOD-17058 | biostudies-arrayexpress
ProteomicsMBOAT7-Driven Lysophosphatidylinositol Acylation in Adipocytes Contributes to Systemic Glucose Homeostasis
We previously demonstrated that antisense oligonucleotide (ASO)-mediated knockdown of Mboat7, the gene encoding Membrane Bound O-Acyltransferase 7, in the liver and adipose tissue of mice promoted high fat diet-induced hepatic steatosis, hyperinsulinemia, and systemic insulin resistance. Thereafter,...
ORGANISM(S): Mus musculus (Mouse) 
2023-05-10 | PXD039894 | Pride
Metabolism Hepatocytes Obesity Phosphatidylinositol biosynthesis Systemic insulin resistance Hyperinsulinemia Arachidonic acid Acyltransferase Non-alcoholic fatty liver disease Diabetes 
ProteomicsT cells and adipocyte IL-17RC control fat innervation and thermogenesis
The sympathetic nervous system innervates peripheral organs to regulate their function and maintain homeostasis, whereas target cells also produce neurotrophic factors to promote sympathetic innervation1,2. The molecular basis of this bi-directional communication is unknown. Here we use thermogenic ...
ORGANISM(S): Mus musculus (Mouse) 
2020-03-02 | PXD017424 | Pride
Tmt based quantitative proteomics Murine brown adipose tissue 
UnknownRandomized Open-Label Phase II Trial of Apitolisib (GDC-0980), a Novel Inhibitor of the PI3K/Mammalian Target of Rapamycin Pathway, Versus Everolimus in Patients With Metastatic Renal Cell Carcinoma.
Not available
S-EPMC5569691 | biostudies-literature
UnknownGenetic inactivation of the polycomb repressive complex 2 in T cell acute lymphoblastic leukemia.
Not available
S-EPMC3274628 | biostudies-literature
MetabolomicsAutomated, Parallel Mass Spectrometry Imaging and Structural Identification of Lipids
We report a method that enables automated data-dependent acquisition of lipid tandem mass spectrometry data in parallel with a high-resolution mass spectrometry imaging experiment. The method does not increase the total image acquisition time and is combined with automatic structural assignment. Thi...
2018-05-21 | MTBLS597 | MetaboLights
UnknownAnalysis of the kidney failure risk equation implementation in routine clinical practice and health inequalities in chronic kidney disease care: a retrospective cohort study.
Not available
S-EPMC11881359 | biostudies-literature
UnknownAssessment of ex vivo antimalarial drug efficacy in African Plasmodium falciparum parasite isolates, 2016-2023: a genotype-phenotype association study.
Not available
S-EPMC12274720 | biostudies-literature
UnknownRich club analysis in the Alzheimer's disease connectome reveals a relatively undisturbed structural core network.
Not available
S-EPMC4504816 | biostudies-literature
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