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ModelsSanchez2017 - Inflammatory responses during acute hyperinsulinemia
Sanchez2017 - Inflammatory responses during acute hyperinsulinemia This model is described in the article: The CD4+ T cell regulatory network mediates inflammatory responses during acute hyperinsulinemia: a simulation study Mariana E. Martinez-Sanchez, Marcia H...
2017-06-27 | MODEL1606020000 | BioModels
TranscriptomicsTranscription profiling of human skeletal muscle response to effect of acute physiologic hyperinsulinemia
This study was undertaken to test the hypothesis that short term exposure (4 hours) to physiologic hyperinsulinemia in normal, healthy subjects without a family history of diabetes would induce a low grade inflammatory response, independently of glycemic status. We performed euglycemic hyperinsuline...
ORGANISM(S): Homo sapiens 
2008-06-16 | E-GEOD-9105 | biostudies-arrayexpress
GenomicsHuman and mouse muscle transcriptomic analyses identify insulin receptor mRNA downregulation in hyperinsulinemia-associated insulin resistance
Human and mouse muscle transcriptomic analyses identify insulin receptor mRNA downregulation in hyperinsulinemia-associated insulin resistance
PRJNA614531 | ENA
GenomicsHyperinsulinemia acts via acinar INSR to drive obesity-associated PDAC initiation by promoting digestive enzyme production and inflammation
Hyperinsulinemia acts via acinar INSR to drive obesity-associated PDAC initiation by promoting digestive enzyme production and inflammation
PRJNA952643 | ENA
UnknownChronic hyperinsulinemia promotes human hepatocyte senescence.
Not available
S-EPMC9364104 | biostudies-literature
TranscriptomicsA zebrafish model for hyperinsulinemia shows that induction of insulin resistance and immune suppression is mediated by ptpn6/shp.1
Type 2 Diabetes, obesity and metabolic syndrome are pathologies impacting a large population worldwide where insulin resistance plays a central role. These pathologies are usually associated to a dysregulation of insulin secretion leading to a chronic exposure of the tissues to high insulin levels (...
ORGANISM(S): Danio rerio 
2014-06-12 | E-GEOD-55836 | biostudies-arrayexpress
TranscriptomicsHyperinsulinemia acts via acinar INSR to drive obesity-associated PDAC initiation by promoting digestive enzyme production and inflammation
The rising incidence of pancreatic cancer is largely driven by the skyrocketing prevalence of obesity and type 2 diabetes (T2D). Hyperinsulinemia is a cardinal feature of both conditions, and is independently associated with increased cancer incidence and mortality. Our previous studies demonstrated...
ORGANISM(S): Mus musculus 
2023-08-01 | GSE229053 | GEO
UnknownDeficiency of PRKD2 triggers hyperinsulinemia and metabolic disorders.
Not available
S-EPMC5964083 | biostudies-literature
TranscriptomicsHuman and mouse muscle transcriptomic analyses identify insulin receptor mRNA downregulation in hyperinsulinemia-associated insulin resistance
Hyperinsulinemia is often viewed as compensatory to insulin resistance, but studies have shown that high levels of insulin may contribute to insulin resistance. The precise mechanisms by which hyperinsulinemia contributes to insulin resistance remain poorly defined. To understand direct effects of p...
ORGANISM(S): Mus musculus 
2020-12-31 | GSE147422 | GEO
UnknownLow-dose naltrexone rescues inflammation and insulin resistance associated with hyperinsulinemia.
Not available
S-EPMC7705311 | biostudies-literature
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