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ProteomicsBiochemical Foundations of Health and Energy Conservation in Hibernating Free-Ranging Subadult Brown Bear Ursus arctos
Brown bears (Ursus arctos) hibernate for 5-7 months without eating, drinking, urinating and defecating at a metabolic rate of only 25% of the summer activity rate. Nonetheless, they emerge healthy and alert in spring. We analyzed the physiological adaptations for hibernation by comparing the proteom...
ORGANISM(S): Ursus arctos arctos (European brown bear) 
2016-09-27 | PXD003946 | Pride
Ursus arctos Brown bear Proteomics Hibernation Lc-ms/ms 
UnknownRandomized Trial of Hepatic Artery Embolization for Hepatocellular Carcinoma Using Doxorubicin-Eluting Microspheres Compared With Embolization With Microspheres Alone.
Not available
S-EPMC4966514 | biostudies-literature
TranscriptomicsTranscription profilfing of human cerebrovascular smooth muscle to identify Ca2+-dependent transcription patterns
Altered Ca2+ handling has both immediate physiological effects and long-term genomic effects on vascular smooth muscle function. Previously we have shown that elevation of cytoplasmic Ca2+ through voltage-dependent Ca2+ channels (VDCCs) or store-operated Ca2+ channels (SOCCs) results in phosphoryla...
ORGANISM(S): Homo sapiens 
2009-04-29 | E-GEOD-2883 | biostudies-arrayexpress
UnknownSingle copy/knock-in models of ALS SOD1 in C. elegans suggest loss and gain of function have different contributions to cholinergic and glutamatergic neurodegeneration.
Not available
S-EPMC6200258 | biostudies-literature
TranscriptomicsTranscription profiling of rat arteries from animals with salt induced hypertensive disease results in over expression of matricellular genes in cerebral arteries
The Dahl salt-sensitive (S) rat model develops chronic hypertensive disease when fed a high salt diet that ultimately results in renal and heart failure, as well as prevalent cerebrovascular pathologies. Phenotypic changes in the cerebral vasculature are preceded by changes in gene expression, and ...
ORGANISM(S): Rattus norvegicus 
2008-06-13 | E-GEOD-5488 | biostudies-arrayexpress
ProteomicsFritz_STK11KO_MIB_2020_TripleTOF5600_complete
The files are associated with a manuscript submitted for publication by Jamie Lee Fritz et al. The main goal of this paper was to identify potential substrates for LKB1, a master kinase that is required for epithelial ovarian cancer spheroid viability and metastasis.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-05-15 | MSV000085415 | MassIVE
ProteomicsFritz_STK11KO_MIB_2020_TripleTOF5600
The files are associated with a manuscript submitted for publication by Jamie Lee Fritz et al. The main goal of this paper was to identify potential substrates for LKB1, a master kinase that is required for epithelial ovarian cancer spheroid viability and metastasis. Both Peak List and Results file...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-04-08 | MSV000085252 | MassIVE
TranscriptomicsThrombopoietin (TPO) protects against heart damage induced infarction in rat model
In order to examine the mechanism of TPO on cardiac protection against myocardial infarction damage (MI), we have employed whole genome microarray expression profiling as a discovery platform to identify genes with the potential to delineate the TPO cardioprotective mechanism against infarction. MI ...
ORGANISM(S): Rattus norvegicus 
2012-12-01 | E-GEOD-22489 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse multipotent adult progenitor cells
We compare the transcriptome of embryonic stem cells (ESCs), adult stem cells with apparent greater differentiation potential such as multipotent adult progenitor cells (MAPCs), mesenchymal stem cells (MSCs) and neurospheres (NS). Mouse and rat MAPCs were used in this study and two different array p...
ORGANISM(S): Mus musculus 
2008-06-15 | E-GEOD-6933 | biostudies-arrayexpress
GenomicForegut Microbiome in Development of Esophageal Adenocarcinoma

The distal esophagus is an important anatomical area where gastric acid reflux can cause reflux esophagitis (RE), Barrett's esophagus (BE) (intestinal metaplasia), and esophageal adenocarcinoma (EA). The incidence of EA has increased 6-fold in the U.S. since the 1970s, parallel to a significa...

phs000260 | dbGaP
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