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Microarray analysis of parity induced gene expression changes in the mammary glands of four strains of rats to identify a common gene signature associated with protection against methylnitrosourea induced mammary tumorigenesis.
ORGANISM(S): Rattus norvegicus 
Independent Lewis rat data used to confirm the finding of the main experiment "Protection against Mammary Tumorigenesis in Multiple Rat Strains (experiment E-TABM-197: https://www.ebi.ac.uk/arrayexpress/experiments/E-TABM-197).
ORGANISM(S): Rattus norvegicus 
Independent FVB mouse data used to confirm the findings of the main experiment "Protection against Mammary Tumorigenesis in Multiple Rat Strains (experiment E-TABM-197: https://www.ebi.ac.uk/arrayexpress/experiments/E-TABM-197).
ORGANISM(S): Mus musculus 
In many mammals, halogenated aromatic hydrocarbon (HAH) exposure causes wasting syndrome, defined as lethal weight loss as a result of severe and persistent hypophagia. The most potent HAH in causing wasting is 2,3,7,8-tetrachlorodibenzo-ρ-dioxin (TCDD), which exerts its toxic effects through the ar...
ORGANISM(S): Rattus norvegicus 
This study has examined the molecular mechanisms underlying sensitivity of sarcomas to Nutlin-3a, a non-genotoxic activator of the p53 pathway. Human patient material was collected immediately following surgical resection, dissected into small pieces and ex planted onto gelatin sponges immersed in m...
ORGANISM(S): Homo sapiens 
Using two different approaches to CK2alpha-silencing, we have used RNA-seq to identify variation in gene-expression of important cell cycle regulators with relevance to heart-associated defects.
ORGANISM(S): Rattus norvegicus 
Estrogen is a reproductive steroid hormone that has both beneficial and detrimental effects on the cardiovascular system. Selective estrogen receptor modulators (SERMs) exhibit partial estrogen agonist/antagonist activity in estrogen target tissues. Since we still have an incomplete picture of the ...
ORGANISM(S): Rattus norvegicus 
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