Sort   by:  
 Page size 
TranscriptomicsGene expression profiles reveal the effect of a high-fat diet in brown fat development
Genome-scale analysis of the genetic factors that govern the development of white and brown adipose tissue is still far from complete. In order to identify the key genes that regulate the development of white and brown adipose tissue in mice, the transcriptome analysis was performed on adipose tissu...
ORGANISM(S): Mus musculus 
2015-01-08 | E-GEOD-64718 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiles of psychostimulant reinforcement in rats
Drug-induced alterations in transcriptional regulation play a central role in establishing the persistent neuroplasticities that occur during drug addiction. Additionally, changes in gene expression associated with drug administration provide valuable insight into the molecular basis of drug abuse. ...
ORGANISM(S): Rattus norvegicus 
2013-06-27 | E-GEOD-43748 | biostudies-arrayexpress
no omics definedTranscription profiling of rat liver and kidney samples performed in 16 different institutions to determine study factors which are key sources of variability. Raw files available as additional archives.
BACKGROUND: The use of gene expression profiling in both clinical and laboratory settings would be enhanced by better characterization of variance due to individual, environmental, and technical factors. Meta-analysis of microarray data from untreated or vehicle-treated animals w...
ORGANISM(S): Rattus norvegicus 
2008-10-10 | E-TOXM-39 | biostudies-arrayexpress
TranscriptomicsLiver Pharmacology and Xenobiotic Response Repertoire
A definition of RNA expression changes that correlate with liver response programs and an understanding of the similarities and differences in responses to different classes of chemicals would aid in new chemical or drug characterization and add to our understanding of liver biology. We have used a ...
ORGANISM(S): Rattus norvegicus 
2008-03-28 | E-GEOD-8858 | biostudies-arrayexpress
Transcriptomicsrat small intestine samples
Experiment description 1. Experimental design 1) Authors, laboratory, and contact: Xue-Lin Cui1, Patricia Soteropoulos2, Peter Tolias2, Ronaldo P. Ferraris1: 1Dept. of Pharmacology and Physiology, UMDNJ-New Jersey Medical School, Newark, NJ 07103-2714, 2Center for Applied Genomics, PHRI, 225 Warre...
ORGANISM(S): Rattus norvegicus 
2010-06-09 | E-GEOD-996 | biostudies-arrayexpress
TranscriptomicsJarid2 regulates hematopoietic stem cell function by acting with Polycomb Repressive Complex 2
Polycomb Repressive Complex 2 (PRC2) has been shown to play a key role in hematopoietic stem and progenitor cell (HSPC) function. Analyses of mouse mutants harboring deletions of core components have implicated PRC2 in fine-tuning multiple pathways that instruct HSPC behavior, yet how PRC2 is target...
ORGANISM(S): Mus musculus 
2015-04-02 | E-GEOD-60808 | biostudies-arrayexpress
TranscriptomicsXenobiotics and loss of cell adhesion drives distinct transcriptional outcomes by Aryl hydrocarbon Receptor (AhR) signaling.
The Aryl hydrocarbon Receptor (AhR) is a signal regulated transcription factor, which is canonically activated by the direct binding of xenobiotics. In addition, switching cells from adherent to suspension culture also activates the AhR, representing a non-xenobiotic, physiological activation of AhR...
ORGANISM(S): Mus musculus 
2012-08-09 | E-GEOD-37144 | biostudies-arrayexpress
UnknownGenome-wide association study provides novel insight into the genetic architecture of severe obesity.
Not available
S-EPMC12443252 | biostudies-literature
UnknownThe genetic determinants of recurrent somatic mutations in 43,693 blood genomes.
Not available
S-EPMC10132750 | biostudies-literature
UnknownGenetic determinants of telomere length from 109,122 ancestrally diverse whole-genome sequences in TOPMed.
Not available
S-EPMC9075703 | biostudies-literature
Sort   by:  
 Page size