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ProteomicsAbnormal mitochondrial structure and function in brown adipose tissue of SLC35A4-MP knockout mice
Uncovering the role of upstream ORFs (uORFs) challenges conventional views of one protein per mRNA while also revealing the capacity of some uORFs to encode microproteins that contribute to cellular biology and physiology. This study explores the functional role of a recently identified mitochondria...
ORGANISM(S): Mus musculus (Mouse) 
2025-07-29 | PXD066679 | Pride
Uorfs Microproteins Slc35a4 Upstream orfs 
GenomicsJmjd3-mediated H3K27me3 dynamics orchestrate brown fat cell fate transition and regulate white fat plasticity
We performed ChIP-seq to chart genome-wide maps of H3K27me3 in brown preadipocytes and mature brown adipocytes. We observed a subset of brown fat-specific genes, but not common fat genes or white fat-specific genes, possess the H3K27me3 mark in preadipocytes, and this mark is erased in mature adipoc...
ORGANISM(S): Mus musculus 
2015-12-31 | E-GEOD-55469 | biostudies-arrayexpress
MetabolomicsAnalysis of sex-specific lipid metabolism of Plasmodium falciparum points to the importance of sphingomyelin for gametocytogenesis
Male and female Plasmodium falciparum gametocytes are the parasite lifecycle stage responsible for transmission of malaria from the human host to the mosquito vector. Not only are gametocytes able to survive in radically different host environments, but they are also precursors for male and female g...
2022-04-05 | MTBLS4137 | MetaboLights
TranscriptomicsBulk RNA seq data from mice lacking ACBP in brown and white adipose tissue
The experimental aim was to examine transcriptional changes in brown and white adipose tissue isolated from Adipoq-Acbp-/- housed at RT and brown adipose tissue isolated from Ucp1-Acbp-/- mice housed at room temperature.
ORGANISM(S): Mus musculus 
2025-03-09 | E-MTAB-14881 | biostudies-arrayexpress
TranscriptomicsGene expression from mouse white, brown, and perivascular adipose tissue
Thoracic perivascular adipose tissue (PVAT) is a unique adipose depot that likely influences vascular function and susceptibility to pathogenesis in obesity and metabolic syndrome. Surprisingly, PVAT has been reported to share characteristics of both brown and white adipose, but a detailed direct co...
ORGANISM(S): Mus musculus 
2011-08-22 | E-GEOD-28440 | biostudies-arrayexpress
MetabolomicsUntargeted metabolomics profiling reveals exercise intensity-dependent alterations in Thoroughbred racehorses’ plasma after routine conditioning sessions

Thoroughbred (TB) racehorses are subjected to rigorous conditioning programs involving exercise sessions of various types, distances and intensities. These programs aim to optimize both their physical and mental capabilities, which are essential to achieve maximal performance. Conventional invest...

2024-01-16 | MTBLS8285 | MetaboLights
ProteomicsArchitecture of the outbred brown fat proteome defines regulators of metabolic physiology
Obesity is a polygenic disorder with variable penetrance in the general population. Brown adipose tissue (BAT) is a major regulator of energy expenditure and metabolic physiology due to a specialized proteome that orchestrates futile metabolic cycles, which could be leveraged to treat obesity. Howev...
ORGANISM(S): Mus musculus (Mouse) 
2022-11-08 | PXD036947 | Pride
Diversity outbred Qtl Physiology Metabolic disease Network Proteome Obesity Phenotype 
TranscriptomicsHuman Trophoblast Responses to P. gingivalis Infection
Porphyromonas gingivalis is a periodontal pathogen that is also associated with preterm low birth weight delivery. We investigated the transcriptional responses of human extravillous trophoblasts (HTR-8) to infection with P. gingivalis. Over 2000 genes were differentially regulated in HTR-8 cells ...
ORGANISM(S): Homo sapiens 
2010-11-02 | E-GEOD-19810 | biostudies-arrayexpress
TranscriptomicsSelf-maintenance of rat C6 glioma stem cells (GSCs) by their non-GSC progenies
Analysis of Hoechst 33342 dye-effluxing side population cells (SP cells defined as glioma stem cells, GSCs) and dye-retaining main population cells (MP cells defined as non-GSCs) that were FACS-sorted from the C6 glioma cell line stably expressing EGFP (C6-eGFP). ECM-related genes, such as Col4a1 an...
ORGANISM(S): Rattus norvegicus 
2016-07-03 | E-GEOD-72431 | biostudies-arrayexpress
TranscriptomicsTranscriptomic profiling of jejunum mucosa of two laying hen strains in response to low dietary Phosphorus
This study investigated changes in gut transcriptome in response to the removal and reduction P (0 and 1 g P/kg feed) during the transition to egg production (at 19 and 24 weeks, before and after the onset of laying) in Lohmann Brown (LB) and Lohmann Selected Leghorn (LSL) chickens. A total of 80 LB...
ORGANISM(S): Gallus gallus 
2024-11-30 | E-MTAB-14040 | biostudies-arrayexpress
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