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ProteomicsChanges in endothelial cell secretome after sirtuin-1 knock-down
Sirtuin1 (Sirt1) in skeletal muscle (SK) and fat protects against metabolic damage by stimulating insulin sensitivity. Here we report that mice with selective deletion of endothelial Sirt1 (E-Sirt1-KO) paradoxically exhibit heightened whole-body insulin sensitivity. Akt phosphorylation, glucose upta...
ORGANISM(S): Homo sapiens (Human) 
2023-08-07 | PXD030565 | Pride
Sirt1 Huvec Secretome 
Proteomics,Multiomicsp53-regulated networks of protein, mRNA, miRNA and lncRNA expression revealed by integrated pSILAC and NGS analyses
We determined the effect of p53 activation on de novo protein synthesis using quantitative proteomics of newly synthesized proteins (pulsed stable isotope labeling with amino acids in cell culture, pSILAC) in combination with mRNA and non-coding RNA expression analyses by next generation sequencing ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-05-24 | MSV000079767 | MassIVE
UnknownInfluence of anesthetic agent and burst suppression on postoperative delirium in elderly patients: a prospective cohort study with automated EEG analysis.
Not available
S-EPMC12835323 | biostudies-literature
TranscriptomicsRac1-Induced Connective Tissue Growth Factor regulates Connexin 43 and N-Cadherin Expression in Atrial Fibrillation
Objectives: We studied the signal transduction of atrial structural remodelling that contributes to the pathogenesis of atrial fibrillation (AF). Backround: Fibrosis is a hallmark of arrhythmogenic structural remodelling but the underlying molecular mechanisms are incompletely understood. Methods: W...
ORGANISM(S): Homo sapiens 
2010-02-21 | E-GEOD-14975 | biostudies-arrayexpress
GenomicsWTCCC2 Pharmacogenomic Response to Statins study
A WTCCC2 project genome-wide study for pharmacogenomic response to statins (PR) in individuals from Scotland.
EGAS00000000121 | EGA
TranscriptomicsReprogramming of mouse gall bladder cells into pancreatic beta cells
Mouse gall bladder cells from MIP-GFP mice were expanded in vitro and transduced with adenoviral vectors expressing the transcription factors Neurog3, Pdx1 and MafA. Reprogrammed GFP+ cells were then FACS-sorted for RNA isolation.
ORGANISM(S): Mus musculus 
2015-04-17 | E-MTAB-3520 | biostudies-arrayexpress
UnknownGenome-wide association study of receptive language ability of 12-year-olds.
Not available
S-EPMC3974169 | biostudies-literature
UnknownA Method to Exploit the Structure of Genetic Ancestry Space to Enhance Case-Control Studies.
Not available
S-EPMC4864319 | biostudies-literature
GenomicsWTCCC2 Reading and Mathematics (RM) samples
A WTCCC2 project genome-wide association study for reading and mathematics ability in 3665 12-year-old individuals from the UK, genotyped on the Affymetrix 6.0 array. Details of the WTCCC2 analysis can be found in Davis et al. [Nat. Commun. 2014 July;5:4204]
EGAS00001000886 | EGA
UnknownCNV analysis in a large schizophrenia sample implicates deletions at 16p12.1 and SLC1A1 and duplications at 1p36.33 and CGNL1.
Not available
S-EPMC3929090 | biostudies-literature
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