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TranscriptomicsGene expression from mouse white, brown, and perivascular adipose tissue
Thoracic perivascular adipose tissue (PVAT) is a unique adipose depot that likely influences vascular function and susceptibility to pathogenesis in obesity and metabolic syndrome. Surprisingly, PVAT has been reported to share characteristics of both brown and white adipose, but a detailed direct co...
ORGANISM(S): Mus musculus 
2011-08-22 | E-GEOD-28440 | biostudies-arrayexpress
TranscriptomicsBlood gene expression of rats exposed to acetaminophen or methyl parathion
The purpose of this study was to investigate whether expression of specific genes in peripheral blood can be used as surrogate marker(s) to detect and distinguish target organ-specific chemical toxicity in rats. Rats were intraperitoneally administered a single, acute dose of a well-established hep...
ORGANISM(S): Rattus norvegicus 
2010-04-08 | E-GEOD-13442 | biostudies-arrayexpress
ProteomicsMudPIT analyses of the proteins co-purified with FLAG-HA Non-Stop FLAG-IPed from Drosophila melanogaster S2 cells
Protein Complexes Purification- Drosophila S2 cells were stably-transfected with pRmHa3-based inducible expression vectors to produce epitope-tagged Non-stop-2xFLAG-2xHA (Non-stop-FH). Cells stably transfected with empty vector served as negative control. Protein complexes containing Non-stop were p...
ORGANISM(S): Drosophila Melanogaster (ncbitaxon:7227) 
2018-07-17 | MSV000082625 | MassIVE
ProteomicsMudPIT analyses of proteins associated with Piccolo and Bassoon in the presynaptic active zone
We used a 3-step protocol that separates lipid-associated proteins based on their buoyant density, size and charge. All steps were conducted either on ice or at 4C. Step 1 involved a sucrose density gradient centrifugation in which ca. 100 postnatal day 4 rat brains were homogenized in buffer A (5...
ORGANISM(S): Rattus Norvegicus (ncbitaxon:10116) 
2016-07-11 | MSV000079897 | MassIVE
TranscriptomicsTCF4 and CDX2, major transcription factors for intestinal function, converge on the same cis-regulatory regions
Surprisingly few pathways signal between cells, raising questions about mechanisms for tissue-specific responses. In particular, Wnt ligands signal in many mammalian tissues, including the intestinal epithelium, where constitutive signaling causes cancer. Genome-wide analysis of DNA cis-regulatory r...
ORGANISM(S): Homo sapiens 
2010-08-11 | E-GEOD-22572 | biostudies-arrayexpress
TranscriptomicsDeep sequencing and proteomics analysis reveal globally dysregulated expression of microRNA and their target genes in rat kidneys treated by carcinogenic dose of Aristolochic Acid
MicroRNAs (miRNAs) play an important role in carcinogenesis by regulating the protein translation from their targeted messenger RNAs (mRNA). Aristolochic Acid (AA) is a potent carcinogen that can induce kidney tumors in both human and experimental animals. Although the expression and roles of miRN...
ORGANISM(S): Rattus norvegicus 
2012-01-01 | E-GEOD-33703 | biostudies-arrayexpress
MetabolomicsMetabolic characterization of directly reprogrammed renal tubular epithelial cells (iRECs)
Fibroblasts can be directly reprogrammed to induced renal tubular epithelial cells (iRECs) using four transcription factors. These engineered cells may be used for disease modeling, cell replacement therapy or drug and toxicity testing. Direct reprogramming induces drastic changes in the transcripti...
2021-08-20 | MTBLS608 | MetaboLights
TranscriptomicsTranscription profiling of purified populations of normal human breast luminal and myoepithelial cells
Purified populations of normal human breast luminal and myoepithelial cells were compared with cDNA microarray analysis.
ORGANISM(S): Homo sapiens 
2004-05-04 | E-MEXP-36 | biostudies-arrayexpress
TranscriptomicsHepatitis B virus-mediated alterations to the primary hepatocyte transcriptome [24 and 48 h]
Purpose: Chronic infection with hepatitis B virus is the leading global risk factor for the development of liver cancer. A large body of research has shown the many effects an HBV infection has on cellular physiology, particularly on pathways that may be involved in the development of HBV-associat...
ORGANISM(S): Rattus norvegicus 
2016-01-15 | E-GEOD-66566 | biostudies-arrayexpress
TranscriptomicsHepatitis B virus-mediated alterations to the primary hepatocyte transcriptome [Full Set]
Purpose: Chronic infection with hepatitis B virus is the leading global risk factor for the development of liver cancer. A large body of research has shown the many effects an HBV infection has on cellular physiology, particularly on pathways that may be involved in the development of HBV-associat...
ORGANISM(S): Rattus norvegicus 
2016-01-20 | E-GEOD-68112 | biostudies-arrayexpress
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