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TranscriptomicsTranscription profiling of rat liver samples from animals treated with D-penicillamine and controls
Idiosyncratic drug reactions (IDRs) cause significant morbidity and mortality. In an animal model of IDRs, 50-80% of Brown Norway rats exposed to D-penicillamine develop an autoimmune syndrome after several weeks of treatment. The symptoms of the IDR are similar to that observed in humans who take D...
ORGANISM(S): Rattus norvegicus 
2007-10-10 | E-GEOD-2825 | biostudies-arrayexpress
TranscriptomicsAutotaxin and its product lysophosphatidic acid suppress brown adipose differentiation and promote diet-induced obesity in mice
Brown adipose tissue (BAT) is a thermogenic organ that dissipates stored energy as heat to maintain body temperature in infants and small mammals. This process may also provide protection from development of diet-induced obesity. We found that the bioactive lipid mediator lysophosphatidic acid (LP...
ORGANISM(S): Mus musculus 
2011-06-01 | E-GEOD-26442 | biostudies-arrayexpress
UnknownA DEL-1/αvβ3 integrin axis promotes brown adipocyte progenitor proliferation and cold-induced brown adipose tissue adaptation.
Not available
S-EPMC12391742 | biostudies-literature
UnknownDevelopment of a large SNPs resource and a low-density SNP array for brown trout (Salmo trutta) population genetics.
Not available
S-EPMC6631668 | biostudies-literature
MetabolomicsThe Lipopolysaccharide-Induced Metabolome Signature in Arabidopsis thaliana Reveals Dynamic Reprogramming of Phytoalexin and Phytoanticipin Pathways
Lipopolysaccharides (LPSs), as MAMP molecules, trigger the activation of signal transduction pathways involved in defence. Currently, plant metabolomics is providing new dimensions into understanding the intracellular adaptive responses to external stimuli. The effect of LPS on the metabolomes of Ar...
2017-05-03 | MTBLS272 | MetaboLights
ProteomicsSystemic effects of pesticides on insectivorous bats: a proteomics approach
Bats play a critical role in controlling agricultural pests, yet foraging in croplands exposes them to hazardous pesticides. These chemicals pose significant risks for bats by impairing immune function, locomotion, and cognition even at low doses, jeopardizing their survival and ecological role. Her...
ORGANISM(S): Eptesicus Fuscus 
2026-04-29 | PXD064919 | panorama
UnknownAcceptability and Preliminary Efficacy of a Novel Web-Based Physical Activity for the Heart (PATH) Intervention Designed to Promote Physical Activity in Adults With Obesity: Protocol for a Pilot Randomized Controlled Trial.
Not available
S-EPMC11962323 | biostudies-literature
MetabolomicsTime-resolved decoding of metabolic signatures of in vitro growth of the hemibiotrophic pathogen Colletotrichum sublineolum
Metabolomics has emerged as a powerful approach to comprehensively interrogate cellular biochemistry. As such, we applied an untargeted liquid chromatography-mass spectrometry metabolomic strategy to elucidate metabolome changes in the anthracnose-causing hemibiotrophic sorghum pathogen, Colletotric...
2022-05-30 | MTBLS735 | MetaboLights
UnknownSelecting a minimal set of androgen receptor assays for screening chemicals.
Not available
S-EPMC8356084 | biostudies-literature
TranscriptomicsPatterns of dioxin-altered mRNA expression in livers of dioxin-sensitive versus dioxin-resistant rats
The dioxin congener 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) causes a wide range of toxic effects in rodent species, all of which are mediated by a ligand-dependent transcription-factor, the aryl hydrocarbon receptor (AHR). The Han/Wistar (Kuopio) (H/W) strain shows exceptional resistance to many ...
ORGANISM(S): Rattus norvegicus 
2011-11-14 | E-GEOD-13513 | biostudies-arrayexpress
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